Skip to main content
Premium Trial:

Request an Annual Quote

Paradigm Genetics, Ingenuity Systems, Millennium Pharmaceuticals, Sun Microsystems, Univ. of Chicago


Paradigm Lays off 50, but Informatics Staff Spared


Paradigm Genetics’ acting CEO John Hamer said last week that despite internal restructuring that resulted in the layoff of 50 employees — 20 percent of its workforce — the company’s informatics staff remains intact.

The layoffs, which primarily affected agricultural research and administrative positions, came as part of a broader restructuring effort within the company, which included the creation of distinct business units for agriculture and human health, a relatively new focus area for the Research Triangle Park, NC-based company.

The informatics team has been split between the business groups to reflect the new project-oriented structure, Hamer said.


Millennium Taps Ingenuity Systems to Create Knowledge Management System


Ingenuity Systems, an Alviso, Calif.-based developer of life science knowledge management solutions, has secured its first customer win with Millennium Pharmaceuticals.

Ingenuity will create a customized knowledge base linking Millennium’s internal research with data from the scientific literature. In turn, Millennium will provide R&D funding to Ingenuity and will make an equity investment in the company.

Ingenuity, founded in October 1998, has developed a proprietary biological ontology and a knowledgebase of over 500,000 findings extracted from the scientific literature and restructured based on the ontology.


U of Chicago Named Sun COE in Bioinformatics


Sun Microsystems has selected the University of Chicago as its latest Center of Excellence in bioinformatics, computational biology and medical informatics.

Sun will install a large computational cluster based on Solaris and Sun’s Grid Engine software. Hardware will include a Sun Fire 6800 enterprise server with 4.6 terabytes of storage housed in Sun StorEdge T3 arrays; a Sun Fire V880 and a Sun Fire 280Rs; a technical compute farm with 52 processors and other servers for high-performance bioinformatics computing; and several dozen Sun Blade 1000 desktops and Sun Ray appliances.

Filed under

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.