Skip to main content
Premium Trial:

Request an Annual Quote

Onyx, Livermore Lab to Collaborate on Proteome

Premium

RICHMOND, Calif.--Onyx Pharmaceuticals and the Lawrence Livermore National Laboratory will collaborate on developing a functional genomics system that can be used in expressing, purifying, and characterizing the components of the majority of proteins expressed in humans, known as the human proteome. Information gained on the human proteome will be used in determining the function of genes that encode the proteins, aiding in the understanding of the human genome.

Researchers from both institutions say the new system will facilitate the identification of therapeutic targets and reduce drug development time. They will initially work to develop a method for converting segments of genes, in the form of cDNA clones, into large numbers of purified proteins. Then they will develop a range of biochemical assays for functional characterization and drug discovery.

The Livermore Lab brings to the deal its position in the academic Integrated Molecular Analysis of Genomes and their Expression (IMAGE) Consortium, which has arrayed over 700,000 human cDNA clones. Over 80 percent of all sequences in public genetic sequence databases are ultimately derive from IMAGE cDNA clones. Onyx brings expertise in expressing proteins and in biochemical analysis of protein interaction and pathways.

The two-year collaboration is funded by the Biotechnology Strategic Targets for Alliances in Research (BioSTAR) project, designed to promote research
partnerships between state universities and businesses in California. Principal investigators are, from Onyx, Robin Clark and Anthony Davies; and from Livermore, Greg Lennon and Joanna Albala.

Filed under

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.