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NSF Bioinformatics Grants Jan. 28 – March 3, 2006

Coding Theoretic Problems in Genetic Data Acquisition, Modeling and Analysis. Start date: Feb. 1, 2007. Expires: Jan. 31, 2009. Awarded amount to date: $151,070. Estimated total award amount: $399,688. Principal investigator: Olgica Milenkovic. Sponsor: University of Colorado at Boulder.
Supports the investigation of “three new coding-theoretic paradigms arising during the processes of genetic data acquisition, analysis, and modeling,” according to the grant abstract. Several classical coding schemes will be “generalized, combined, and optimized for a given application.” The research is expected to have “significant impact” on the development of cDNA and aptamer microarrays.

Multiscale Modeling of Nanoparticle-Cell Interactions. Start date: March 1, 2007.
Expires: Feb. 29, 2012. Awarded amount to date: $401,000. Estimated total award: $401,000. Principal investigator: Sulin Zhang. Sponsor: University of Arkansas.
Project aims to examine the nanoparticle-cell interaction mechanisms at the molecular level through a novel multiscale model that links atomistic simulations, meso-scale particle dynamics, continuum mechanics, and chemical kinetics. “Critical interrelationships between surface and physical properties of the nanoparticles (particle size, shape, topology, ligand-receptor binding affinity, etc.) and their cellular uptake rate and endocytic pathways will be established,” according to the patent abstract. The computational tools developed from the proposed research are expected to aid the research community in addressing “fundamentally important issues at nano-bio interfaces that cannot be explored systematically and quantitatively by experiments alone.”

Development of CREMA: A High Throughput Method for the Identification of Promoter Mutations. Start date: March 1, 2007. Expires: Feb. 29, 2008. Awarded amount to date: $101,699. Principal investigator: Erich Grotewold. Sponsor: Ohio State University Research Foundation.
Funds development of CREMA (Cis Regulatory Element Mutational Analysis), an approach that integrates genetics, molecular biology, and bioinformatics in order to identify point mutations in promoters and other regulatory regions. In this project, CREMA will be tested with a small subset of well characterized Arabidopsis promoters.

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The Scan

US Booster Eligibility Decision

The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions.

Arizona Bill Before Judge

The Arizona Daily Star reports that a judge weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction.

Additional Genes

Wales is rolling out new genetic testing service for cancer patients, according to BBC News.

Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.