Skip to main content
Premium Trial:

Request an Annual Quote

NIH Establishes Full-Length Mammalian cDNA Initiative

Premium

WASHINGTON--The US National Institutes of Health announced a full-length cDNA initiative this month to support the development of technologies that will facilitate the generation of a complete set of full-length human and other mammalian cDNA.

According to the institutes, current methods of cDNA clone and library production favor shorter, more heavily represented genes. Methods for isolating mRNA for use in cDNA construction work well with cell lines, but reliable methodologies for extraction of high-quality mRNA from tissues remains a challenge, the institutes said, adding that reliable, high-throughput methods to determine whether clones contain a copy of the full transcript, the full coding region, or a partial transcript are needed.

The program will be managed by a transinstitutes steering committee and will "ultimately provide a gold-standard set of reagents for use by the research community," the institute said. Letters of intent are due to the institutes April 6.

Filed under

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.