Skip to main content
Premium Trial:

Request an Annual Quote

NIGMS-funded Michigan Center to Serve as Drug Development Data Resource

NEW YORK (GenomeWeb News) – The University of Michigan will create a new molecular data center that will serve as a free resource for drug designers and pharmacology software developers, according to the National Institutes of Health.
 
The five-year program, called the Community Structure-Activity Resource, will receive up to $5 million over five years through the National Institute of General Medical Sciences.
 
The CSAR will collect molecular data from existing resources, will work with other researchers to generate new data, and will be involved in collecting unpublished data from researchers at pharmaceutical companies.
 
"If we know the structure of a compound bound to a drug target, we should be able to tell how tightly the compound binds — information critical to drug development,” NIGMS Director Jeremy Berg said in a statement.
 
“But, in practice, we are not able to do this well enough to contribute significantly to research progress,” he said. "This resource has been established to make important structural and binding data available so researchers can tackle this problem."
 
The program will be led by UM College of Pharmacy chemist Heather Carlson, who will oversee the development and operation of CSAR.
 
The researchers also will use Carlson’s Binding MOAD (“Mother of All Databases”), which holds over 11,000 protein-ligand complexes, and the PDBbind database, which provides experimentally measured binding data.
 
CSAR scientists also will try to use experiments to close gaps in the data, and will sponsor community-wide events to spur more scientific collaboration.
 

Filed under

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.