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NIEHS Seeks Feedback on Methods for Functional Validation of Environmentally Relevant SNPs

NEW YORK (Genome Web News) – The National Institute of Environmental Health Sciences has issued a request for information on methods for testing the functional significance of SNPs and other genetic variants associated with susceptibility to environmental exposures
 
The RFI, “Functional Validation of Environmentally-Responsive Genetic Variants,” available here, seeks comments from the research community “regarding how polymorphisms or genetic variants identified through genetic association studies, candidate gene studies, or epidemiological studies for environmentally relevant diseases can best be validated in functional prescreens and studies.”
 
NIEHS said in the RFI that it welcomes information on available resources and tools for studying the functional significance of these genetic variants, as well as feedback on further resources, tools, or services that may be needed.
 
“As the performance of whole genome-wide association studies for numerous complex diseases becomes realistic, it is becoming increasingly apparent that there is a need for better resources and tools to test the functional significance of environmentally relevant SNPs and genetic variants in order to move these discoveries to final prediction of disease risk and therapeutic interventions,” NIEHS said.  
 
Specifically, NIEHS is seeking comment on high-throughput assays and screens, cell-based assays and cell line resources, computational and bioinformatics tools, “high-data content” technologies, RNAi and siRNA silencing approaches, and environmental challenges.
 
Responses should be submitted here by April 20, 2007.

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