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NHGRI to Support New Technology Development


BETHESDA, Md.--The US National Human Genome Research Institute announced that money is available to support the advanced development of methods, hardware, and software technologies for genomic research with an emphasis on sequencing technologies. The institute expects to be able to fund the program with $5 million-$10 million in fiscal year 1999, and with an additional $10 million in each of the next two fiscal years. It will address technologies for which proof of principle has been demonstrated but for which additional support is needed in order to develop robust, efficient tools for use in publicly supported high-throughput genomics laboratories. Grant applications are now being accepted. Information is available at

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The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.