Skip to main content
Premium Trial:

Request an Annual Quote

New York Stem Cell Foundation, Harvard Catalyst's Eagle-I to Create Open Access Stem Cell Database

NEW YORK (GenomeWeb) – The New York Stem Cell Foundation Research Institute has teamed with the open source eagle-I Network to create a database of iPS cell lines and related information for use in stem cell research projects, NYSCF said this week.

The Induced Pluripotent Stem Cell database will be a searchable, web-based resource that will be publicly available to investigators seeking to find iPS information, to collaborate with other investigators, and to avoid duplicating work that has already been done. NYSCF said this will be the first iPS cell database that is easily searchable and open to researchers, and that the lack of such a resource has been "a major obstacle to the implementation of iPS technology."

Under the partnership, NYSCF will work with eagle-I, an open access discovery platform funded by Harvard Catalyst (The Harvard Clinical and Translational Science Center), to establish a repository of information on a large number of iPS cells. Eagle-I will display this information as linked open data.

NYSCF uses its Global Stem Cell Array technology, an automated high-throughput tool for producing and differentiating cells, to derive hundreds of stem cell lines from skin samples of patients with a range of diseases. The new database will enable researchers to search through these iPS cell lines under several categories — by disease, how the cells were reprogrammed, and patient age at the time the sample was collected.

Future versions of the database will include genomic and other clinical and cellular phenotype data, and it will be possible for scientists to order lines directly through the website, NYSCF said.

"It is important to have open access to available resources, and this collaboration with eagle-i is a prime example of interdisciplinary teams working together to provide this for the scientific community," NYSCF CEO Susan Solomon said in a statement.

The partners plan to present the alpha version of the database this month at the International Society for Stem Cell Research conference in Vancouver, British Columbia.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.