Skip to main content
Premium Trial:

Request an Annual Quote

New Sequence Analysis Tool, Available on Web, Has Discovered a Gene


SANTA FE, NM--The National Center for Genome Resources, a nonprofit bioinformatics organization here, has released MAR-Finder, a new computer-based gene sequence analysis tool, on its web site at MAR-Finder can be used to identify DNA regions involved in attachment to the nuclear matrix, according to the center.

MAR-Finder was developed by senior computational scientist Gautam Singh. It uses statistical inference to deduce the presence of matrix association regions, or MAR's, in DNA sequences. MAR's constitute a significant functional block within sequences and facilitate differential gene expression and DNA replication, he said. The tool has already been used by Stephen Krawetz, an associate professor at the Center for Molecular Medicine and Genetics at Wayne State University and collaborator with Singh, to discover a new human gene, known as SOCS-1, which is involved in human cytokine-mediated signal transduction.

"MAR-Finder is a valuable tool and its development was a nice meld between a dry and wet lab. You can detect a matrix association region with the computer and test your prediction at the bench that same day," Krawetz commented. "And, appreciation for the role of MARs in controlling the expression of our genome is growing." An enhanced version of MAR-Finder with even more power is due out in the middle of the year.

Filed under

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.