LOS ANGELES--The latest release of Net-ID's hidden Markov model simulator for biological sequence analysis, HMMpro 2.1, is now available at the company's web site, http://www.netid.com. The tool's graphical user interface allows users interactively to build, fine-tune, and analyze models of protein families or DNA functional elements that can then be used for multiple alignments, pattern discovery, and sensitive data mining, according to Net-ID. Highlights of the new version include a command-line interface for easy scripting, choice of various background models, local multiple alignments and scoring, and platform support for Silicon Graphics workstations, Solaris, and Windows NT.