NEW YORK – Two independent teams of researchers have developed methods that allow them to assemble haplotype-resolved human genomes without the use of parental data.
Both groups published their respective papers on Monday in Nature Biotechnology. The methods are similar in concept but use different technologies — single-cell strand sequencing (Strand-seq) and the Hi-C assay, respectively, said Tobias Marschall, a professor at Heinrich Heine University Düsseldorf in Germany and senior author of one of the papers.