New Computational Model Predicts Timing, Roadblocks in Transcription Factor Binding | GenomeWeb

Scientists at Uppsala University and Harvard have built a computational model that addresses the effects of transcription factor crowding and DNA looping on the process of a transcription factor finding its target site. Their model can better predict the effect that roadblocks, or other macromolecules that bind to DNA, have on TF diffusion as well as suggest a role for DNA looping in speeding up the time it takes a TF to find it target site.

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