SAN DIEGO--The US National Cancer Institute has awarded a $100,000 Small Business Innovation Research grant to Structural Bioinformatics to support its work developing nonpeptide small-molecule antagonists targeting the HER2 breast cancer-related gene. The government funding will enable Structural Bioinformatics' scientists to apply the company's proprietary protein modeling and dynamic pharmacophore-based searching of existing and virtual combinatorial libraries to identify and synthesize putative small-molecule HER2 antagonists. The company said it will first use its patented and proprietary algorithms to model the dynamic surface of the target protein, and then to extract 3D-pharmacophore structural information used to computationally prescreen large-scale small-molecule compound libraries for likely drug activity. Structural Bioinformatics has already successfully applied this technology to six clinically important protein targets on behalf of three corporate pharmaceutical collaborators in the past 18 months, in each case generating series of antagonists for each target in the viral protease, protein kinase, hormone, and apoptosis areas.
NCI Awards SBIR Grant to Structural Bioinformatics
Apr 23, 1999