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MWG Biotech, Sapphire Version 3.2, GelFox 3.0, Sequence Manipulation Suite, Sockeye

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Ebersberg, Germany-based MWG Biotech has released a free web-based siRNA design tool as part of its e-commerce portal [see story, p. 1]. The new service allows customers to design siRNA oligonucleotides to silence specific genes and order them from the company's website. The tool includes a Blast function that checks every candidate siRNA to see which gene or alternative splice form it matches. There is also a sense-strand Blast function to detect and avoid non-specific off-target effects.


LabVantage Solutions said last week that it has begun shipping its Sapphire Version 3.2 LIMS system. Key enhancements include improved 21 CFR Part 11 capabilities, support for Oracle 9i, and an enhanced Java API.


Imaxia of Cupertino, Calif., is offering a 25-day free trial version of its GelFox 3.0 image processing software for 2D gel electrophoresis analysis at http://www.imaxia.com/download/GelFox30.exe. The product key for the trial is GELFOX-YTF45-QH3KL-M9XB6. The price for a single-seat license is $4,800 for commercial users and $3,360 for academic users.


Version 2 of the Sequence Manipulation Suite, a collection of JavaScript programs for generating, formatting, and analyzing short DNA and protein sequences, is available from the University of Alberta at http://bioinformatics.org/sms2/. The new version now accepts multiple sequences as input.


Version 1.1 of the Sockeye three-dimensional genome browser is available from the Michael Smith Genome Science Center at http://www.bcgsc.ca/gc/bomge. The latest version of the software is available for Linux and Windows and offers improved functionality for comparative genomics in an improved user interface, including “semantic zooming” to permit querying very large genomic regions.

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The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.