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Lion Target Engine, SRS-GeneSpring Connectors, DrugMatrix, GenBank, SAS BioBundle, GENSAT, MAGEstk API


Lion Bioscience and Silicon Genetics have released their jointly developed Lion Target Engine and SRS-GeneSpring Connectors, which allow GeneSpring users to easily transfer data to and from the Lion Target Engine and SRS data and analysis tool integration platform. The SRS-GeneSpring Connector also provides an SRS page with pre-defined queries tailored for gene expression data analysis.

Iconix Pharmaceuticals has released version 2.30 of its DrugMatrix chemogenomics database. New features include support for data cartridge chemical structure search algorithms, a gene expression profile query tool, a molecular pharmacology profile query tool, a Gene Ontology analysis tool, and a pathway impact analysis tool.

GenBank release 138.0 is now available from NCBI at The release contains 35,599,621,471 base pairs and 29,819,397 entries, up by 1,734,599,220 base pairs and 2,605,649 sequence records from the August 137.0 release. Uncompressed, the 138.0 flat files require about 118 GB for the sequence files only. The ASN.1 version requires around 105 GB.

As part of a broad new set of information management offerings for small to medium-sized businesses, IBM has partnered with SAS to offer the SAS BioBundle —a combination of SAS analytical applicationsand IBM eServer Unix and Intel systems and storage.

Data from the Gene Expression Nervous System Atlas (GENSAT) BAC Transgenic Project, led by researchers at Rockefeller University, is freely available at The atlas contains micrographic images depicting the gene expression of the central nervous system of the mouse based on bacterial artificial chromosomes.

A new version of the Java MAGEstk API — a software toolkit for implementing the MAGE object model — is available from the MGED consortium at


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The Scan

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Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.