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Lexicon and DuPont Ink Deal on Mouse Genomics


THE WOODLANDS, Texas--DuPont Pharmaceuticals has subscribed to Lexicon Genetic's OmniBank gene sequence database, which includes over 30,000 ES cell clones and a library of mutant mouse clones. Lexicon received a license and certain sublicensing rights to a patented DuPont technology used to create tissue-specific gene knockouts.

The agreement marks Lexicon's third OmniBank subscription. Within three years, Lexicon expects that OmniBank, which it said is growing at a rate of over 1,000 clones per week, will contain ES cell clones and OmniBank Sequence Tags representing gene trap insertions in virtually all mouse genes.

Lexicon also announced that it has obtained broad US patent coverage of methods for using isogenic DNA technology to modify the genomes from multicellular animals. The most common use of the technology is for efficient production of knockout mice.

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