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Jim Hopkins, Claire Fraser-Liggett, Christian Reich, Richard Lingard

Tripos Discovery Informatics has appointed Jim Hopkins as CEO, following the sale of the firm last week to Vector Capital (see feature story, this issue). The company also appointed Richard Cramer as chief scientific officer and Robert Clark as vice president of research.
Hopkins was most recently chairman and CEO of Micrografx, a graphics software company that was sold to Corel.
Cramer has served as the vice president for science at Tripos for the past 24 years and Clark was most recently vice president of scientific research and director of Tripos Informatics Research Center.

Claire Fraser-Liggett has resigned as president of the Institute for Genomic Research and will leave TIGR on April 20, BioInform’s sister publication GenomeWeb Daily News reported this week.
It was not immediately clear who will take her place at TIGR, which is a division of the J. Craig Venter Institute. Fraser-Liggett has been president and director of TIGR since September 1998.

Genstruct has appointed Christian Reich as vice president of scientific research. Reich has worked at the European Bioinformatics Institute and served as global head of clinical informatics for Millennium Pharmaceuticals before joining the company.

Richard Lingard has joined DeltaDot as vice president of sales. Lingard was previously director of strategic alliances at Invitrogen, vice president of business development at Argenta Discovery, director of business development at Inpharmatica (now part of Galapagos), and director of sales for Genomica (now part of Exelixis). Lingard has also held business development positions at Accelrys and Merck.

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The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.