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James Rubin, John Yingling, Jasper Rine, Nicholas Jewell, and International Society for Computational Biology

James Rubin resigned as CFO of Tripos on Oct. 12, the company disclosed in a filing with the US Securities and Exchange Commission this week. Rubin will remain a senior vice president at the firm, working full time through Oct. 31 and with a reduced workload after that date. Tripos’ board appointed John Yingling, vice president and chief accounting officer, to replace Rubin as CFO.

Jasper Rine, professor of molecular and cell biology at the University of California, Berkeley, has been appointed director of UC Berkeley’s Center for Computational Biology for a three-year term, effective immediately. Rine replaces Nicholas Jewell, professor of biostatistics and statistics, who served as the initiative's acting director for two years.


The International Society for Computational Biology is seeking nominations for the seventh annual Overton Prize and the fifth annual Senior Scientist Accomplishment Award. Winners of both awards will be invited to present keynote talks at the joint conference of the Intelligent Systems for Molecular Biology and the European Conference of Computational Biology in Vienna, Austria, July 21-25, 2007. Nominations can be submitted here no later than Nov. 30.

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The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.