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IP Update: University of Chicago, Hitachi Among Recent Bioinformatics Patent Winners


US Patent 8,116,988. Method for indexing nucleic acid sequences for computer based searching. Inventors: Benjamin Glick, William Stokes. Assignees: The University of Chicago, GSL Biotech

Describes a method for indexing DNA databases that uses an algorithm, dubbed K-mer Indexing with Compact Arrays, or MICA, to index sequences based on unique k-mers within the sequence. The resulting index can be searched to generate a list of exact matches for query sequences.

US Patent 8,112,230. Method of network-based identification of multicomponent synergy and compositions for use as effective component of anti-angiogenesis medicines. Inventors: Ningbo Zhang, Shao Li, Bo Zhang. Assignee: Tsinghua University

The patent abstract describes a computerized approach to determine the effects of administering a combination of two medicines on diseases. The approach uses disease-related gene networks to analyze genes that respond to treatments.

US Patent 8,108,152. Method for redesign of microbial production systems. Inventors: Costas Maranas, Anthony Burgard, Priti Pharkya. Assignee: The Penn State Research Foundation

Describes a computational framework, dubbed OptStrain, for modifying microbial metabolic pathways to enable increased production of targeted compounds for use in biofuels as well as drug precursor molecules.

US Patent 8,103,368. Information processing system using nucleotide sequence-related information. Inventors: Takamasa Kato, Takeo Morimoto. Assignee: Hitachi

Describes a system for providing semantic information about individual organisms based on variations in genomic sequences such as SNPs.

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.