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IP Update: University of Chicago, Hitachi Among Recent Bioinformatics Patent Winners

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US Patent 8,116,988. Method for indexing nucleic acid sequences for computer based searching. Inventors: Benjamin Glick, William Stokes. Assignees: The University of Chicago, GSL Biotech

Describes a method for indexing DNA databases that uses an algorithm, dubbed K-mer Indexing with Compact Arrays, or MICA, to index sequences based on unique k-mers within the sequence. The resulting index can be searched to generate a list of exact matches for query sequences.


US Patent 8,112,230. Method of network-based identification of multicomponent synergy and compositions for use as effective component of anti-angiogenesis medicines. Inventors: Ningbo Zhang, Shao Li, Bo Zhang. Assignee: Tsinghua University

The patent abstract describes a computerized approach to determine the effects of administering a combination of two medicines on diseases. The approach uses disease-related gene networks to analyze genes that respond to treatments.


US Patent 8,108,152. Method for redesign of microbial production systems. Inventors: Costas Maranas, Anthony Burgard, Priti Pharkya. Assignee: The Penn State Research Foundation

Describes a computational framework, dubbed OptStrain, for modifying microbial metabolic pathways to enable increased production of targeted compounds for use in biofuels as well as drug precursor molecules.


US Patent 8,103,368. Information processing system using nucleotide sequence-related information. Inventors: Takamasa Kato, Takeo Morimoto. Assignee: Hitachi

Describes a system for providing semantic information about individual organisms based on variations in genomic sequences such as SNPs.


The Scan

Study Reveals Details of SARS-CoV-2 Spread Across Brazil

A genomic analysis in Nature Microbiology explores how SARS-CoV-2 spread into, across, and from Brazil.

New Study Highlights Utility of Mutation Testing in Anaplastic Thyroid Cancer

Genetic mutations in BRAF and RAS are associated with patient outcomes in anaplastic thyroid carcinoma, a new JCO Precision Oncology study reports.

Study Points to Increased Risk of Dangerous Blood Clots in COVID-19 Patients

An analysis in JAMA Internal Medicine finds that even mild COVID-19 increases risk of venous thromboembolism.

Y Chromosome Study Reveals Details on Timing of Human Settlement in Americas

A Y chromosome-based analysis suggests South America may have first been settled more than 18,000 years ago, according to a new PLOS One study.