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IP Update: SmartGene, IBM, SoftGenetics among Recent Bioinformatics Patent Winners

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US Patent 8,275,557. Computer-implemented method and computer-based system for validating DNA sequencing data. Inventor: Stefan Emler. Assignee: SmartGene

Describes a computerized method of validating DNA fragments using reference sequences.


US Patent 8,275,555. Method and system for comparative genomics. Inventors: Gad Landau, Laxmi Priya Parida, Oren Weimann. Assignee: International Business Machines

Describes a method and system for comparing genomic data that involves “providing a PQ tree that represents gene clusters that are common to at least two genomes.”


US Patent 8,271,427. Computer database system for single molecule data management and analysis. Inventors: David Charles Schwartz, Christopher Churas, Galex Yen. Assignee: Wisconsin Alumni Research Foundation

Describes a database system for storing, processing, displaying, and analyzing single molecule data that can manage and process different formats and kinds of data and display it upon request.


US Patent 8,271,206. DNA sequence assembly methods of short reads. Inventors: Jonathan Changsheng, Yiqiong Wu, Kevin Jay LeVan. Assignee: SoftGenetics

Describes a computerized method for automatically assembling short DNA fragments into larger ones.


US Patent 8,271,203. Methods and systems for sequence-based design of multiple reaction monitoring transitions and experiments. Inventors: Christie Hunter, Alpesh Patel. Assignee: DH Technologies Development

Describes computer-implemented methods for designing selective- and multiple-reaction monitoring experiments for identifying proteins and peptides of interest.


The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.