Skip to main content
Premium Trial:

Request an Annual Quote

IP Update: In Silico Biosciences, Pathwork Diagnostics among Recent Bioinformatics Patent Winners


US Patent 8,332,158. Method and apparatus for computer modeling of the interaction between and among cortical and subcortical areas in the human brain for the purpose of predicting the effect of drugs in psychiatric and cognitive diseases. Inventors: Hugo Geerts, Athan Spiros. Assignee: In Silico Biosciences

Describes a method of modeling interactions between and among cortico and subcortical areas of the human brain that can be used to study the clinical effects of drugs on psychiatric and cognitive diseases such as schizophrenia, bipolar disorder, major depression, ADHD, autism, obsessive-compulsive disorder, and substance abuse.

US Patent 8,326,547. Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm. Inventors: Xiaowu Liu, Yun He, Zhuying Wang, Chunjiao Wang, Zhibing Liu, Tianhui Xia, Luquan Wang, Fang Liang Zhang. Assignee: Nanjingjinsirui Science & Technology Biology Corporation

Describes a method for sequence optimization to improve recombinant protein expression in bacteria, yeast, insect, and mammalian cells that uses a particle swarm optimization algorithm.

US Patent 8,321,147. Statistical approach for optimal use of genetic information collected on historical pedigrees, genotyped with dense marker maps, into routine pedigree analysis of active maize breeding populations. Inventors: Marinus Bink, Carl ter Braak, Oscar Smith, Radu Totir. Assignees: Pioneer Hi-Bred International, Wageningen University, Stichting Dienst Landbouwkundig Onderzoek

Describes a method of predicting plant phenotypes that “incorporates previously unusable dense marker data derived from historical pedigrees.” According to the abstract, the method works by collecting loci information from a population, which is used to build matrices by calculating the probability that alleles present at the loci are identical by descent. These matrices are then used to develop a second set of matrices — where “each value represents the probability that a certain individual in the population descended from a certain ancestral (founder) genotype” — which can then be used as part of a breeding program.

US Patent 8,321,137. Knowledge-based storage of diagnostic models. Inventors: Quang Tran, Glenda Anderson, Alejandrina Pattin, Cheryl Kay Hornbaker. Assignee: Pathwork Diagnostics
Describes methods, computer systems, and a computer-readable medium for testing models used to classify biological specimens.

US Patent 8,321,136. Method and systems for classifying slides using scatter plot distribution. Inventors: Kam Lin Wong, Louise Isenstein, David Zahniser. Assignee: CYTYC

Describes methods for classifying biological specimens that use “nuclear area and nuclear integrated optical density” to generate scatter plots.

Filed under

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.