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IP Update: In Silico Biosciences, Pathwork Diagnostics among Recent Bioinformatics Patent Winners

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US Patent 8,332,158. Method and apparatus for computer modeling of the interaction between and among cortical and subcortical areas in the human brain for the purpose of predicting the effect of drugs in psychiatric and cognitive diseases. Inventors: Hugo Geerts, Athan Spiros. Assignee: In Silico Biosciences

Describes a method of modeling interactions between and among cortico and subcortical areas of the human brain that can be used to study the clinical effects of drugs on psychiatric and cognitive diseases such as schizophrenia, bipolar disorder, major depression, ADHD, autism, obsessive-compulsive disorder, and substance abuse.


US Patent 8,326,547. Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm. Inventors: Xiaowu Liu, Yun He, Zhuying Wang, Chunjiao Wang, Zhibing Liu, Tianhui Xia, Luquan Wang, Fang Liang Zhang. Assignee: Nanjingjinsirui Science & Technology Biology Corporation

Describes a method for sequence optimization to improve recombinant protein expression in bacteria, yeast, insect, and mammalian cells that uses a particle swarm optimization algorithm.


US Patent 8,321,147. Statistical approach for optimal use of genetic information collected on historical pedigrees, genotyped with dense marker maps, into routine pedigree analysis of active maize breeding populations. Inventors: Marinus Bink, Carl ter Braak, Oscar Smith, Radu Totir. Assignees: Pioneer Hi-Bred International, Wageningen University, Stichting Dienst Landbouwkundig Onderzoek

Describes a method of predicting plant phenotypes that “incorporates previously unusable dense marker data derived from historical pedigrees.” According to the abstract, the method works by collecting loci information from a population, which is used to build matrices by calculating the probability that alleles present at the loci are identical by descent. These matrices are then used to develop a second set of matrices — where “each value represents the probability that a certain individual in the population descended from a certain ancestral (founder) genotype” — which can then be used as part of a breeding program.


US Patent 8,321,137. Knowledge-based storage of diagnostic models. Inventors: Quang Tran, Glenda Anderson, Alejandrina Pattin, Cheryl Kay Hornbaker. Assignee: Pathwork Diagnostics
Describes methods, computer systems, and a computer-readable medium for testing models used to classify biological specimens.


US Patent 8,321,136. Method and systems for classifying slides using scatter plot distribution. Inventors: Kam Lin Wong, Louise Isenstein, David Zahniser. Assignee: CYTYC

Describes methods for classifying biological specimens that use “nuclear area and nuclear integrated optical density” to generate scatter plots.


Filed under

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.