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IP Update: Pacific Biosciences, University of North Carolina, Charlotte among Recent Bioinformatics Patent Winners

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US Patent 8, 374,837. Descriptors of three-dimensional objects, uses thereof and a method to generate the same. Inventors: Hans Louis Jos De Winter, Roger Gert Wilfried Langenaeker. Assignee: Silicos

Describes a computerized method of generating descriptors of three-dimensional objects for use in drug discovery. The descriptors can be used to study structure activity relationships, for virtual screening of molecular databases, and for synthesizing virtual molecules with predefined properties.


US Patent 8, 374,828. Computer implemented system for protein and drug target design utilizing quantified stability and flexibility relationships to control function. Inventors: Donald Jacobs, Dennis Livesay. Assignee: University of North Carolina, Charlotte

Describes a method of computationally designing the quantitative stability/flexibility relationships between proteins and their molecular targets.


US Patent 8, 370,079. Algorithms for sequence determination. Inventors: Jon Sorenson, Susan Tang, Patrick Marks, Chen-Shan Chin. Assignee: Pacific Biosciences

Describes improvements to algorithms for consensus sequence determination from replicate biomolecule sequence data.


US Patent 8, 370,074. Systems and methods for predicting transmembrane domains in membrane proteins and mining the genome for recognizing G-protein coupled receptors. Inventors: Rene Trabanino, Nagarajan Vaidehi, Spencer Hall, William Goddard, Wely Floriano. Assignee: California Institute of Technology

Describes molecular dynamics and modeling methods that are used to predict the presence of protein transmembrane regions and protein structural models.


US Patent 8, 364,408. Global alignment of sequence data. Inventor: Deepak Srinivasa. Assignee: International Business Machines

Describes a method of determining the optimal alignment of two molecules.


The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.