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IP Update: Pacific Biosciences, University of North Carolina, Charlotte among Recent Bioinformatics Patent Winners


US Patent 8, 374,837. Descriptors of three-dimensional objects, uses thereof and a method to generate the same. Inventors: Hans Louis Jos De Winter, Roger Gert Wilfried Langenaeker. Assignee: Silicos

Describes a computerized method of generating descriptors of three-dimensional objects for use in drug discovery. The descriptors can be used to study structure activity relationships, for virtual screening of molecular databases, and for synthesizing virtual molecules with predefined properties.

US Patent 8, 374,828. Computer implemented system for protein and drug target design utilizing quantified stability and flexibility relationships to control function. Inventors: Donald Jacobs, Dennis Livesay. Assignee: University of North Carolina, Charlotte

Describes a method of computationally designing the quantitative stability/flexibility relationships between proteins and their molecular targets.

US Patent 8, 370,079. Algorithms for sequence determination. Inventors: Jon Sorenson, Susan Tang, Patrick Marks, Chen-Shan Chin. Assignee: Pacific Biosciences

Describes improvements to algorithms for consensus sequence determination from replicate biomolecule sequence data.

US Patent 8, 370,074. Systems and methods for predicting transmembrane domains in membrane proteins and mining the genome for recognizing G-protein coupled receptors. Inventors: Rene Trabanino, Nagarajan Vaidehi, Spencer Hall, William Goddard, Wely Floriano. Assignee: California Institute of Technology

Describes molecular dynamics and modeling methods that are used to predict the presence of protein transmembrane regions and protein structural models.

US Patent 8, 364,408. Global alignment of sequence data. Inventor: Deepak Srinivasa. Assignee: International Business Machines

Describes a method of determining the optimal alignment of two molecules.

The Scan

Y Chromosome Study Reveals Details on Timing of Human Settlement in Americas

A Y chromosome-based analysis suggests South America may have first been settled more than 18,000 years ago, according to a new PLOS One study.

New Insights Into TP53-Driven Cancer

Researchers examine in Nature how TP53 mutations arise and spark tumor development.

Mapping Single-Cell Genomic, Transcriptomic Landscapes of Colorectal Cancer

In Genome Medicine, researchers present a map of single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer.

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.