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IP Update: Pacific Biosciences, University of North Carolina, Charlotte among Recent Bioinformatics Patent Winners


US Patent 8, 374,837. Descriptors of three-dimensional objects, uses thereof and a method to generate the same. Inventors: Hans Louis Jos De Winter, Roger Gert Wilfried Langenaeker. Assignee: Silicos

Describes a computerized method of generating descriptors of three-dimensional objects for use in drug discovery. The descriptors can be used to study structure activity relationships, for virtual screening of molecular databases, and for synthesizing virtual molecules with predefined properties.

US Patent 8, 374,828. Computer implemented system for protein and drug target design utilizing quantified stability and flexibility relationships to control function. Inventors: Donald Jacobs, Dennis Livesay. Assignee: University of North Carolina, Charlotte

Describes a method of computationally designing the quantitative stability/flexibility relationships between proteins and their molecular targets.

US Patent 8, 370,079. Algorithms for sequence determination. Inventors: Jon Sorenson, Susan Tang, Patrick Marks, Chen-Shan Chin. Assignee: Pacific Biosciences

Describes improvements to algorithms for consensus sequence determination from replicate biomolecule sequence data.

US Patent 8, 370,074. Systems and methods for predicting transmembrane domains in membrane proteins and mining the genome for recognizing G-protein coupled receptors. Inventors: Rene Trabanino, Nagarajan Vaidehi, Spencer Hall, William Goddard, Wely Floriano. Assignee: California Institute of Technology

Describes molecular dynamics and modeling methods that are used to predict the presence of protein transmembrane regions and protein structural models.

US Patent 8, 364,408. Global alignment of sequence data. Inventor: Deepak Srinivasa. Assignee: International Business Machines

Describes a method of determining the optimal alignment of two molecules.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.