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IP Update: Metabolon, U of Tennessee, New York University Among Recent Bioinformatics Patent Winners


US Patent 8,155,887. Computer visualized drug interaction information retrieval. Inventor: Leigh Rothschild. Assignee: SRR Patent Holdings

Describes an approach for visualizing and retrieving drug interaction data. According to the abstract, the method includes tools for acquiring images of different compounds and then detecting content in these images that indicate the identity of each substance in question. It can also be used to retrieve drug interaction data for each identified compound and to find correlations with other drugs.

US Patent 8,140,311. Computer aided ligand-based and receptor-based drug design utilizing molecular shape and electrostatic complementarity. Inventor: Randy J. Zauhar; William J. Welsh. Assignee: Not listed

Describes methods for generating shape signatures that represent molecular shapes and electrostatic potential, using ligand-based and receptor-based molecular design.

US Patent 8,140,271. Least-square deconvolution (LSD): a method to resolve DNA mixtures. Inventors: Tse-Wei Wang, John Douglas Birdwell, Xue Ning, Mark S. Rader, John Flaherty. Assignee: University of Tennessee Research Foundation

Describes a mathematical approach for resolving mixtures of DNA. According to the patent abstract, the method uses "quantitative allele peak data" that is derived from the DNA "to resolve the best-fit genotype profile of each contributor." The method is based on "finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data."

US Patent 8,140,270. Methods and systems for medical sequencing analysis. Inventors: Stephen Kingsmore, Damian G. Gessler, Gregory D. May, Joann Mudge. Assignee: National Center for Genome Resources

Describes a computerized approach for identifying elements associated with complex diseases such as links between genetic variants and phenotypes.

US Patent 8,140,269. Methods, computer-accessible medium, and systems for generating a genome wide haplotype sequence. Inventor: Bhubaneswar Mishra, Thomas Anantharaman, Sang Lim. Assignee: New York University

Describes a computerized approach for using genome-wide probe maps to generate genome-wide haplotype sequences.

US Patent 8,140,268. Computational method for drug discovery and receptor design. Inventor: Michael Jason Potter, Gilson Rodman, Hillary Sue, Michael Kenneth Gilson. Assignee: VeraChem

Describes computational methods for "predicting the mutual affinity of two molecules for each other in solution." According to the patent abstract, the method could be used in the design and discovery of drug molecules that work by binding targeted macromolecules. The method could also be used to design targeted binding molecules such as synthetic receptors for applications like drug-delivery, chemical sensing, separation and purification, and self-assembling molecular structures.

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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.