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IP Update: Metabolon, U of Tennessee, New York University Among Recent Bioinformatics Patent Winners


US Patent 8,155,887. Computer visualized drug interaction information retrieval. Inventor: Leigh Rothschild. Assignee: SRR Patent Holdings

Describes an approach for visualizing and retrieving drug interaction data. According to the abstract, the method includes tools for acquiring images of different compounds and then detecting content in these images that indicate the identity of each substance in question. It can also be used to retrieve drug interaction data for each identified compound and to find correlations with other drugs.

US Patent 8,140,311. Computer aided ligand-based and receptor-based drug design utilizing molecular shape and electrostatic complementarity. Inventor: Randy J. Zauhar; William J. Welsh. Assignee: Not listed

Describes methods for generating shape signatures that represent molecular shapes and electrostatic potential, using ligand-based and receptor-based molecular design.

US Patent 8,140,271. Least-square deconvolution (LSD): a method to resolve DNA mixtures. Inventors: Tse-Wei Wang, John Douglas Birdwell, Xue Ning, Mark S. Rader, John Flaherty. Assignee: University of Tennessee Research Foundation

Describes a mathematical approach for resolving mixtures of DNA. According to the patent abstract, the method uses "quantitative allele peak data" that is derived from the DNA "to resolve the best-fit genotype profile of each contributor." The method is based on "finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data."

US Patent 8,140,270. Methods and systems for medical sequencing analysis. Inventors: Stephen Kingsmore, Damian G. Gessler, Gregory D. May, Joann Mudge. Assignee: National Center for Genome Resources

Describes a computerized approach for identifying elements associated with complex diseases such as links between genetic variants and phenotypes.

US Patent 8,140,269. Methods, computer-accessible medium, and systems for generating a genome wide haplotype sequence. Inventor: Bhubaneswar Mishra, Thomas Anantharaman, Sang Lim. Assignee: New York University

Describes a computerized approach for using genome-wide probe maps to generate genome-wide haplotype sequences.

US Patent 8,140,268. Computational method for drug discovery and receptor design. Inventor: Michael Jason Potter, Gilson Rodman, Hillary Sue, Michael Kenneth Gilson. Assignee: VeraChem

Describes computational methods for "predicting the mutual affinity of two molecules for each other in solution." According to the patent abstract, the method could be used in the design and discovery of drug molecules that work by binding targeted macromolecules. The method could also be used to design targeted binding molecules such as synthetic receptors for applications like drug-delivery, chemical sensing, separation and purification, and self-assembling molecular structures.

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The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.