US Patent 8,090,543. Computer algorithm for automatic allele determination from fluorometer genotyping device. Inventor: Stephen Glanowski, Jeremy Heil, Emily Winn-Deen, Ivy McMullen. Assignee: Applied Biosystems (Life Technologies)
Describes a method for "allelic classification" of DNA samples by cluster-based analysis of emission spectra observed from fluorophore-labeled nucleotide probes
US Patent 8,086,414. Method and system for modeling cellular metabolism. Inventor: Costas Maranas, Anthony Burgard. Assignee: The Penn State Research Foundation
Describes a method for in silico modeling of cellular metabolism. The method improves on flux balance analysis models because it incorporates several constraints including qualitative kinetic information, qualitative regulatory information, and DNA microarray data. The approach also includes computational procedures for solving metabolic problems.
US Patent 8,086,410. Methods of detecting DNA variation in sequence data. Inventor: Changsheng Liu, Fei Gao.
Describes a mathematical method using trace data from sample sequences to detect DNA variation.
US Patent 8,082,109. Computer-aided discovery of biomarker profiles in complex biological systems. Inventor: William Ladd, Keith Elliston, Joseph Loureiro. Assignee: Selventa
Describes a computational approach for identifying candidate biomarkers in body fluids and tissue samples.