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IP Update: Life Tech, Penn State, Selventa Among Recent US Patent Winners

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US Patent 8,090,543. Computer algorithm for automatic allele determination from fluorometer genotyping device. Inventor: Stephen Glanowski, Jeremy Heil, Emily Winn-Deen, Ivy McMullen. Assignee: Applied Biosystems (Life Technologies)

Describes a method for "allelic classification" of DNA samples by cluster-based analysis of emission spectra observed from fluorophore-labeled nucleotide probes


US Patent 8,086,414. Method and system for modeling cellular metabolism. Inventor: Costas Maranas, Anthony Burgard. Assignee: The Penn State Research Foundation

Describes a method for in silico modeling of cellular metabolism. The method improves on flux balance analysis models because it incorporates several constraints including qualitative kinetic information, qualitative regulatory information, and DNA microarray data. The approach also includes computational procedures for solving metabolic problems.


US Patent 8,086,410. Methods of detecting DNA variation in sequence data. Inventor: Changsheng Liu, Fei Gao.

Describes a mathematical method using trace data from sample sequences to detect DNA variation.


US Patent 8,082,109. Computer-aided discovery of biomarker profiles in complex biological systems. Inventor: William Ladd, Keith Elliston, Joseph Loureiro. Assignee: Selventa

Describes a computational approach for identifying candidate biomarkers in body fluids and tissue samples.


The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.