US Patent 8,494,779. Method for screening essential metabolites in growth of microorganisms Inventors: Sang Yup Lee, Hawoong Jeong, Tae Yong Kim, Pan-Jun Kim, Kwang Ho Lee. Assignee: Korea Advanced Institute of Science and Technology
This patent is for a method of screening metabolites in microorganisms that uses metabolic flux analysis. According to the abstract, the method involves constructing a metabolic network of the microorganism, "inactivating the consumption reaction of each of metabolites" in the network model, "analyzing the metabolic flux of the metabolites to select metabolites [that are] essential for the growth of the microorganism, and confirming the selected metabolites using the utilization of each of the metabolites, defined as flux sum."
US Patent 8,483,972. System and method for genotype analysis and enhanced Monte Carlo simulation method to estimate misclassification rate in automated genotyping Inventor: Sami Kanderian. Assignee: Canon US Life Sciences
The patent is for methods and systems for analyzing nucleic acids' dissociation behavior. The abstract further states that the patent covers methods and systems for "calculating error statistics for an assay for identifying a genotype in a biological sample using an enhanced Monte Carlo simulation method."
US Patent 8,483,971. System and method and computer program for non-binary sequence comparison Inventor: Jeffrey Clark. Assignee: Not listed
The patent covers a system and method for "performing non-binary comparison of biological sequences" that includes a new measure called "omega0, which is a non-binary counting measure that is used in a stand alone module called VaSSA-1." According to the abstract, "this measure obtains substantially more information about sequences and comparisons between them than is gathered by conventional bioinformatics techniques."
US Patent 8,478,537. Methods and systems for clustering biological assay data Inventor: Nicholas Sampas. Assignee: Agilent Technologies
This patent covers statistical methods of clustering data from biological assays.
US Patent 8,478,535. Systems and methods that utilize machine learning algorithms to facilitate assembly of AIDS vaccine cocktails Inventors: Nebojsa Jojic, Vladimir Jojic, David Heckerman, Brendan John Frey, Christopher Meek. Assignee: Microsoft Corporation
According to the abstract, this patent covers systems and methods based on machine learning algorithms for generating vaccine cocktails for pathogens "that evolve quickly under immune pressure of the host" such as HIV.
US Patent 8,473,221. Process, software arrangement and computer-accessible medium for obtaining information associated with a haplotype Inventors: Will Casey, Tom Anantharaman, Bhubaneswar Mishra. Assignees: New York University, Wisconsin Alumni Research Foundation
According to the abstract, this patent relates to a method, system, and software for "determining the co-associations of allele types across consecutive loci and hence for reconstructing two haplotypes of a diploid individual from genotype data." The inventors believe that their approach could be help with genetics-based disease diagnosis and treatment.