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IP Update: May 20, 2011

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Recent Patents in Bioinformatics, April — May 2011

US Patent 7,945,392. Methods and systems for drug screening and computational modeling based on biologically realistic neurons. Inventors: Peter Siekmeier, Steven Matthysse. Assignee: McLean Hospital Corporation.

The patent describes a method for screening a test drug for potential efficacy in treating schizophrenia. The abstract states that the approach includes "a computer model" that represents "a volume of disease-afflicted neural tissue comprising biologically realistic neurons" that are exposed to the potential drug for a period of time. The outcome of the exposure indicates whether the drug is a likely candidate for treating the disease.


US Patent 7,945,389. Information processing system using nucleotide sequence-related information. Inventors: Takamasa Kato, Takeo Morimoto. Assignee: Hitachi.

Describes a method for processing information on nucleotide sequences. The system will provide positional information on nucleotide sequences as well as associated semantic information.


US Patent 7,941,278. MicroRNA motifs. Inventors: Yu-Ching Chang, Yu-Yu Lin, Shiu-Chieh Lan, Cheng-Tao Wu, Chung-Cheng Liu. Assignee: Industrial Technology Research Institute.

The patent describes the development of computational methods for predicting microRNA motifs for a target gene or a set of target genes.


The Scan

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.

Sequencing Study Leads to Vaccine Target in Bacteria Behind Neonatal Meningitis

Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal meningitis in mouse models of the disease.

Multiple Myeloma Progression Influenced by Immune Microenvironment Expression

Researchers in NPJ Genomic Medicine compare RNA sequencing profiles of 102,207 individual cells in bone marrow samples from 18 individuals with rapid or non-progressing multiple myeloma.

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.