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IP Update: Mar 25, 2011

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Recent Patents in Bioinformatics, February 2011 — March 2011

US Patent 7,912,650. Information processing system using nucleotide sequence-related information. Inventors: Takamasa Kato, Takeo Morimoto. Assignee: Hitachi.

Describes a system for processing information on nucleotide sequences. Specifically, the patent abstract states that the method will be used to process information for "providing semantic information and/or information associated with the semantic information useful for each individual organism through effective utilization of differences in nucleotide sequence-related information among individual organisms"


US Patent 7,904,250. Computer software to assist in identifying SNPs with microarrays. Inventors: Michael Molla, Todd Richmond, Steven Smith, Thomas Albert. Assignee: Roche Nimblegen.

The patent describes a method to identify SNPs from microarray hybridization data.


US Patent 7,890,445. Model selection for cluster data analysis. Inventors: Asa Ben Hur, Andre Elisseeff, Isabelle Guyon. Assignee: Health Discovery Corporation.

Describes a method for "choosing the number of clusters, or more generally the parameters of a clustering algorithm" that is based on comparing the "similarity between pairs of clustering runs on sub-samples or other perturbations of the data."


US Patent 7,890,313. Method and apparatus for analysis of molecular combination based on computations of shape complementarity using basis expansions. Inventors: David Kita, Somalee Datta, Adityo Prakash, Eniko Fodor. Assignee: Verseon.

The patent abstract describes a method for molecular combinations that feature two or more molecular subsets. According to the investigators, it "computes the shape complementarity of the system utilizing a basis expansion representing molecular shapes of the first and second molecular subsets in a coordinate system."


The Scan

Y Chromosome Study Reveals Details on Timing of Human Settlement in Americas

A Y chromosome-based analysis suggests South America may have first been settled more than 18,000 years ago, according to a new PLOS One study.

New Insights Into TP53-Driven Cancer

Researchers examine in Nature how TP53 mutations arise and spark tumor development.

Mapping Single-Cell Genomic, Transcriptomic Landscapes of Colorectal Cancer

In Genome Medicine, researchers present a map of single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer.

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.