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IP Update: Jun 24, 2011

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Recent Patents in Bioinformatics, May — June 2011

US Patent 7,966,338. Computer-directed assembly of a polynucleotide encoding a target polypeptide. Inventors: Glen A. Evans. Assignee: Johnson & Johnson

Describes a method for using the results of genomic sequence information generated by computer-directed polynucleotide assembly and based upon information in resources such as the human genome database. The abstract states that the approach may be used to select, synthesize, and assemble novel, synthetic target polynucleotide sequences that encode a target polypeptide.


US Patent 7,962,291. Methods and computer software for detecting splice variants. Inventors: Alan Williams, Simon Cawley, John E. Blume, Hui Wang, Tyson Clark. Assignee: Affymetrix

Describes a computer-implemented method for analyzing and identifying alternative splicing that involves normalizing a probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.


US Patent 7,962,289. System, method, and computer product for exon array analysis. Inventors: Alan J. Williams, Charles W. Sugnet, James H. Gorrell. Assignee: Affymetrix

The patent describes a method analyzing data generated by probe arrays. According to the abstract, the approach involves identifying a subset of intensity values from a biological probe array as well as parameters to process the data and use the information to identify biological events.


The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.