Recent Patents in Bioinformatics, May — June 2011
US Patent 7,966,338. Computer-directed assembly of a polynucleotide encoding a target polypeptide. Inventors: Glen A. Evans. Assignee: Johnson & Johnson
Describes a method for using the results of genomic sequence information generated by computer-directed polynucleotide assembly and based upon information in resources such as the human genome database. The abstract states that the approach may be used to select, synthesize, and assemble novel, synthetic target polynucleotide sequences that encode a target polypeptide.
US Patent 7,962,291. Methods and computer software for detecting splice variants. Inventors: Alan Williams, Simon Cawley, John E. Blume, Hui Wang, Tyson Clark. Assignee: Affymetrix
Describes a computer-implemented method for analyzing and identifying alternative splicing that involves normalizing a probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.
US Patent 7,962,289. System, method, and computer product for exon array analysis. Inventors: Alan J. Williams, Charles W. Sugnet, James H. Gorrell. Assignee: Affymetrix
The patent describes a method analyzing data generated by probe arrays. According to the abstract, the approach involves identifying a subset of intensity values from a biological probe array as well as parameters to process the data and use the information to identify biological events.