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InforMax, GeneEd, GenBank


InforMax of Bethesda, Md., has released LabShare for Vector NTI, a multi-user environment for data exchange using the Vector NTI software. LabShare is based upon a centralized relational database. According to the company, it offers an intuitive GUI to simplify data import, export, viewing, editing, and searching, as well as a web-based administration interface to streamline system administration tasks, including defining user groups, providing data access privileges, and configuring data viewing capabilities. InforMax said it plans to announce the launch of additional Vector products within the next two weeks.

A number of new tools related to the Gene Ontology have been released recently:

The Saccharomyces Genome Database has created a tutorial to help users become familiar with Gene Ontology and the GO annotations available at SGD. It can be found at: Saccharomyces/help/gotutorial.html.

MPATH (Mouse Pathology Ontology), a new addition to the GOBO (Global Open Biological Ontologies) set of shared controlled vocabularies, is available at:

GeneEd said it would soon release GO-KDS (Gene Ontology Knowledge Discovery System), a complete classification of 12 million PubMed documents according to the GO taxonomy. Both GO-KDS and the underlying classification engine are available for licensing. GeneEd is offering free trials of the system. Those interested in participating should contact: [email protected].

GenBank Release 131.0 is now available from the National Center for Biotechnology Information at and mirror sites ( and Release 131.0 contains 22,616,937,182 base pairs and 18,197,119 entries, up by 1.968 billion base pairs and 725,989 sequence records from the July 130.0 release. Uncompressed, the 131.0 flat files require around 74.82 GB for the sequence files only. The ASN.1 version requires around 65.92 GB.

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The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.