Skip to main content
Premium Trial:

Request an Annual Quote

Immunex Will Use ArQule Technology to Target Immune System

Premium

MEDFORD, Mass.--ArQule, a drug discovery chemistry company here, will collaborate with Seattle biopharmaceutical Immunex to discover and develop products for the treatment of inflammatory disorders. Immunex will gain access to ArQule's mapping array program, comprised of libraries of novel, diverse, small organic, pure compounds used for screening against biological targets in new product discovery. Immunex will use the program to identify small molecule therapeutics based on a chemokine gene discovered by the Seattle company.

ArQule will use proprietary assays from Immunex that utilize a novel inhibitor of multiple chemokines to identify compounds with biological activity from ArQule's Mapping Array program. The data it provides are expected to speed the identification of specific active drug leads. Once those are identified, Immunex will elect whether to continue preclinical development with ArQule, or to license the active leads in exchange for milestone and royalty payments to ArQule for successful clinical and commercial development. Financial terms were not disclosed.

Filed under

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.