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Idea pkExpress, MDL Decision Manager, IDRAC, Cytoscape, SeqAlert, ProSup, Genetic Association Database, ConSite


Lion Bioscience has launched Idea pkExpress, a predictive ADME (absorption, distribution, metabolism, and elimination) solution for lead optimization. The system is built upon the company’s Idea ADME prediction software and includes Lion’s new Distribution and Elimination Model, which enables users to predict the pharmacokinetic parameters of new chemical entities.

MDL Information Systems has released MDL Decision Manager, a collaborative workspace system for drug discovery researchers engaged in lead selection, validation, and optimization.

Liquent has released an updated version of IDRAC, a database of regulatory affairs information for 33 countries. The new version offers a more user-friendly interface and advanced search and navigation features, according to the company.

Version 1.1 of Cytoscape, visualization software to depict molecular interactions developed by researchers at the Whitehead Institute and the Institute for Systems Biology, is available at download/index.html.

The Weizmann Institute has released SeqAlert, a sequence-alerting service that periodically compares protein sequences of interest against sequences from determined 3D structures in the Protein Data Bank and TargetDB, at

An updated version of ProSup, a protein structure comparison server from the University of Salzburg, is available at

The Center for Information Technology at the National Institute on Aging has released the Genetic Association Database at, which allows users to compare human microarray or proteomic data against human genetic association in the context of common human disease.

ConSite, a program to detect transcription factor binding sites using phylogenetic footprinting, is available from the Center for Molecular Medicine and Therapeutics at the University of British Columbia at


Filed under

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.