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IDBS, In Silico Discovery, Unilever, Genomatica, Cognia, Integrated Genomics, Mascoma, ACD/Labs, GSK, NIDDK, GeneGo

IDBS, In Silico Discovery Integrate Software
IDBS and In Silico Discovery have agreed to integrate IDBS’ pharmaceutical data management tools, including its new E-WorkBook technology, with In Silico Discovery’s K3 integration platform.
The combined platform will enable researchers to “construct project-specific queries via creation of a virtual data warehouse,” the companies said in a statement.

Unilever Expands Partnership With Genomatica
Genomatica said last week that Unilever has agreed to expand a collaboration that the companies began in 2005. 
Under the expanded agreement, the companies will use Genomatica's metabolic modeling and simulation technologies to “accelerate the development of novel ingredients to improve the effectiveness of Unilever products,” Genomatica said in a statement. 
Financial details of the agreement were not disclosed, but include research and development support, technology license fees, and milestone payments with Genomatica retaining commercial rights to discoveries for applications outside of Unilever's fields of interest.

Cognia to Expand UK Presence, Add 50 Jobs by Year End
Cognia said this week that it will add 50 jobs to its UK operations by the end of the year.
The company, based in New York, opened a UK subsidiary with 10 employees in early 2005 as part of a three-year text-mining collaboration with the University of Edinburgh [BioInform 03-21-05].
Cognia said this week that the program has “far exceeded” its expectations and that it plans to add a corporate service office in Cambridge, UK, with around 50 employees.

Integrated Genomics to Annotate Microbe Genome for Mascoma
Integrated Genomics said this week that it has signed a contract with Mascoma to annotate the genome of a microbe important to breaking down cellulosic biomass for conversion into ethanol.
Integrated Genomics will use its ERGO bioinformatics platform to annotate the genome and reconstruct its metabolic pathways.
Mascoma has also licensed the ERGO Bioinformatics Suite for in-house use.
The annotation project is expected to run through the end of the year.

ACD/Labs to Develop Solubility Prediction Algorithms for GSK
Advanced Chemistry Development said this week that it is collaborating with GlaxoSmithKline to develop an algorithm for predicting solubility in aqueous DMSO solution as well as “related enhancements” to its pKa and aqueous solubility prediction algorithms.
The algorithms will be derived from “tens of thousands of experimentally determined data points provided by GSK, likely one of the largest such data sets measured under uniform and controlled experimental conditions,” ACD/Labs said in a statement.

NIDDK Renews License to GeneGo’s Metacore
GeneGo said this week that the National Institute of Diabetes and Digestive and Kidney Diseases has renewed its license to GeneGo’s MetaCore pathway analysis platform as part of a research collaboration on functional analysis of insulin-resistant diabetes in human and animal models.
Financial terms of the agreement were not disclosed.

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The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.