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Health Discovery Corp., CambridgeSoft, Molecular Connections, Thermo Fisher, GeneData, Henkel, Kyoto Prefectural University, Ariadne, Sigma-Aldrich

Health Discovery Corp. Secures $2.1M Cash Infusion, Converts $2.1M Debt Into Equity
Health Discovery Corp. has announced the close of an equity investment totaling $2.1 million with a financial institution and other accredited investors. The company’s directors also participated in the financing, HDC said.
The company said it also plans to convert into equity $2.1 million of previously issued secured debt.
The combination of  the investment and the debt conversion increases the company’s equity base by around $4.2 million.

CambridgeSoft and Molecular Connections Ally on NetPro Database
Indian informatics company Molecular Connections has appointed CambridgeSoft as developer, marketer, and seller for its NetPro small-molecule interactions database.
Under the agreement, Cambridge, Mass.-based CambridgeSoft will use its ChemOffice technology to develop a version of NetPro that is searchable by chemical structure.
NetPro offers information relevant to drug interactions and metabolism, enzyme kinetics, and potential therapeutic agents, including data about drugs, molecules with therapeutic potential, metabolites, physiologically available bioactive molecules, ligands, agonists, antagonists, enzyme activators, enzyme inhibitors, bio-hazardous molecules, carcinogens, and toxicants.
The companies said the integrated product will allow chemists to find information on nearly 86,000 small-molecule interactions.

Thermo Fisher’s LIMS Solutions Web-Enabled in Microsoft Pact
Thermo Fisher Scientific said this week that it is web-enabling its laboratory information management systems by tapping Microsoft’s ClickOnce deployment technology.
This allows Thermo Fisher to create a solution combining functionality and performance of the desktop client via the web, the company said.
Unlike most LIMS, which are based on a client-server model, a web-enabled LIMS only needs to be installed once on a central server, and then a URL is sent to users, which allows them to run the application in a "sandbox" on their desktops, Thermo said.
According to the company, this approach minimizes the risk of application conflicts that are often associated with client installations and reduces the amount of time and resources IT departments need to install and maintain the LIMS infrastructure.

GeneData Joins Henkel in ‘White Biotech’ Project
Genedata said this week that it has signed a five-year pact with Henkel, a home care, personal care, and adhesives technologies provider, under the company’s Genomic Design Initiative.
Henkel will use Genedata’s Phylosopher software to investigate genomic methods for improving the performance of microorganisms such as Bacillus licheniformis.
The company will use Phylosopher as its “central infrastructure” in the project, Genedata said.
Henkel will use the software to gather copious data output from transcriptomics, metabolomics, and proteomics experiments during industrial fermentation processes. This data is expected to aid metabolic reconstruction and improve the understanding of critical regulatory networks, helping researchers identify and eliminate the factors limiting production yields, Genedata said.

Ariadne Licenses Pathway Studio to Kyoto Prefectural University
Kyoto Prefectural University of Medicine has licensed  Ariadne Genomics’ Pathway Studio Enterprise software, the company said this week.
The university will use the software for pathway and microarray data analysis as well as the storage of experimental data. It will also serve as a reference database for functional relations in humans and rodents.
Kozo Kawahara, president of World Fusion, Ariadne’s distributor of enterprise products in Japan, said the university chose the software because it offers daily updates from the PubMed database as well as gene set enrichment analysis for identifying pathways affected by experiments.

Sigma-Aldrich Partners with Ingenuity to Improve Biological Search Engine
Sigma-Aldrich and Ingenuity Systems have announced a partnership to enhance the search capabilities for Sigma’s existing e-commerce platform.
Under terms of the agreement, Sigma-Aldrich will integrate Ingenuity’s knowledge base of biological networks and search technology into its online life science product portfolio.
The new search capability will be freely available to researchers, allowing them to locate and buy the company’s products that are most relevant for their research and understand them “in a content-rich environment elucidating biological and chemical relationships,” the companies said.

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The Scan

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Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.