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HapMap Release 21, UCSC Genome Browser, siVirus

The International HapMap Project has made genotypes, frequencies, and assays for phase I and phase II of the HapMap project available for bulk download at HapMap Release 21 contains all processed data from the HapMap project, as well as genotypes from the Affymetrix 500K genotyping array.

The Genome Bioinformatics Group at the University of California Santa Cruz has released a Genome Browser for the Build 2, version 1, assembly of the chimpanzee (Pan troglodytes) genome. The 6X whole-genome assembly contains sequence from the initial 4X assembly published in Nature last year, with additional 2X sequence from the Genome Sequencing Center of Washington University School of Medicine. The assembly covers about 97 percent of the genome and is composed of 265,882 contigs. Bulk downloads of the sequence and annotation data are available via FTP ( or the UCSC downloads page (

The University of Tokyo has launched siVirus, a web-based antiviral siRNA design tool that searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences, according to the researchers. The software, which currently covers HIV-1, hepatitis C, SARS, and influenza, is available at

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The Scan

US Supports Patent Waivers

NPR reports that the Biden Administration has announced its support for waiving intellectual property protections for SARS-CoV-2 vaccines.

Vaccines Versus Variants

Two studies find the Pfizer-BioNTech SARS-CoV-2 vaccine to be effective against viral variants, and Moderna reports on booster shots to combat variants.

CRISPR for What Ails You

The Wall Street Journal writes that CRISPR-based therapies could someday be used to treat common conditions like heart attacks.

Nature Papers Review Integration of Single-Cell Assay Data, Present Approach to Detect Rare Variants

In Nature this week: review of ways to integrate data from single-cell assays, and more.