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HapMap Release 21, UCSC Genome Browser, siVirus

The International HapMap Project has made genotypes, frequencies, and assays for phase I and phase II of the HapMap project available for bulk download at HapMap Release 21 contains all processed data from the HapMap project, as well as genotypes from the Affymetrix 500K genotyping array.

The Genome Bioinformatics Group at the University of California Santa Cruz has released a Genome Browser for the Build 2, version 1, assembly of the chimpanzee (Pan troglodytes) genome. The 6X whole-genome assembly contains sequence from the initial 4X assembly published in Nature last year, with additional 2X sequence from the Genome Sequencing Center of Washington University School of Medicine. The assembly covers about 97 percent of the genome and is composed of 265,882 contigs. Bulk downloads of the sequence and annotation data are available via FTP ( or the UCSC downloads page (

The University of Tokyo has launched siVirus, a web-based antiviral siRNA design tool that searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences, according to the researchers. The software, which currently covers HIV-1, hepatitis C, SARS, and influenza, is available at

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The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.