Skip to main content
Premium Trial:

Request an Annual Quote

Genzyme Earns Patent on Serial Analysis Of Gene Expression


FRAMINGHAM, Mass.--Genzyme Molecular Oncology here has received a US patent on its Serial Analysis of Gene Expression (SAGE) technology. The patent was issued to scientists at Johns Hopkins University from the laboratories of Kenneth Kinzler and Bert Vogelstein. The Genzyme division obtained an exclusive license to SAGE as a result of its parent company's acquisition of PharmaGenics last year.

"SAGE's powerful technology has the ability to expand the discovery of commercial targets, reduce development time, and improve competitiveness for both our own and our customers' product development efforts," commented Gail Maderis, president of Genzyme Molecular Oncology. SAGE works by analyzing short pieces of genetic information, called SAGE tags, from expressed genes that exist in a given cell. The tags are linked together for efficient sequencing analysis.

In other news, the company also announced last month that it has signed a collaborative agreement with the US National Cancer Institute to search for new chemotherapy drugs. The collaboration will combine Genzyme's expertise in combinatorial chemistry and its 1 million-compound library with the institute's array of 60 cell-based cancer screens. Based on screening results, clinical development agreements will be negotiated for each compound the two parties choose to pursue. Genzyme will retain commercial rights to lead compounds identified under the collaboration.

Filed under

The Scan

Not Yet a Permanent One

NPR says the lack of a permanent Food and Drug Administration commissioner has "flummoxed" public health officials.

Unfair Targeting

Technology Review writes that a new report says the US has been unfairly targeting Chinese and Chinese-American individuals in economic espionage cases.

Limited Rapid Testing

The New York Times wonders why rapid tests for COVID-19 are not widely available in the US.

Genome Research Papers on IPAFinder, Structural Variant Expression Effects, Single-Cell RNA-Seq Markers

In Genome Research this week: IPAFinder method to detect intronic polyadenylation, influence of structural variants on gene expression, and more.