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Genome Analyzer, ADMET Predictor 3.0, Reactome 25, MiMI, BioPuppy

Genomatix Software has released Genomatix Genome Analyzer, or GGA, an integrated hardware/software solution for analyzing data from second-generation sequencers.
Genomatix said the system is designed for ChIP-seq and transcriptome studies. Results include clustered and classified enriched regions, transcription factor over-representation, and TF associations.
In addition, researchers can use the software to study genome-wide correlations with genomic features, as well as meta-analysis with genome-wide chromatin modification, methylation state, expression levels, or any data derived via next-generation sequencers, the company said.
GGA is driven by a browser-based interface. All database structures, scripts, and tools are accessible and can be tailored to the user’s needs, the company said.

Simulations Plus has released ADMET Predictor 3.0, which predicts the properties of molecules based on their structure. The upgrade includes 14 new predicted properties as well as new retrained models for the predictions. 
Among the new prediction tools are eight models for metabolic inhibition and five for intrinsic clearance that have been added to the software’s Enslein Metabolism Module. The initial Enslein Metabolism Module predicted metabolic rate of certain enzymes but not the potential for metabolic inhibition that can cause interactions with other drugs metabolized by the same enzymes, the company said.
The company has also added a new environmental toxicity prediction based on data originally generated by the US Environmental Protection Agency.
Another enhancement to ADMET Predictor is the addition of a graphics engine called Miner3D, which allows scientists to visualize multidimensional relationships among properties and descriptors.

Version 25 of the Reactome knowledgebase is accessible here.
New additions include an expanded and reorganized pathway module for biological oxidations, along with several new pathway topics: glutamate neurotransmitter release cycle, beta cell development, and integrin cell surface interactions. Pathway topics updated with new curated events include: apoptosis/regulatory reactions, metabolism of amino acids/ODC regulation, metabolism of vitamins, NGF signaling, and lipid metabolism/HDL synthesis.
In addition, a beta version of a new pathway visualization tool is available, along with a new search tool.

The University of Michigan has released an updated version of the MiMI plug-in for Cytoscape, whichprovides access to an integrated resource of molecular interaction data, literature links, and annotation. 

A beta version of BioPuppy 1.0 is available here.  
BioPuppy is a minimal Linux electronic workbench for bioinformatics and computational biology designed to meet the needs of beginners, according to its developers.
BioPuppy is available as a CD with ready-to-use bioinformatics tools, including the sequence analysis tools Sim-4, Genewise, Sigma, HMMer, ClustalW, and mafft; the structure prediction tools mfold and gibbs; the protein structure analysis tools Garlic and Rasmol; the phylogenetic analysis tools Fast DNA, Phylip, and Phylodraw; Modeller for protein modeling; MGL Tools for docking; and the Copasi systems biology tool.

Filed under

The Scan

More Boosters for US

Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.

From a Pig

A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.

For Privacy's Sake

Wired reports that more US states are passing genetic privacy laws.

Science Paper on How Poaching Drove Evolution in African Elephants

In Science this week: poaching has led to the rapid evolution of tuskless African elephants.