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GeneSpring 7, Signet 5, Cytoscape, Omega 1.8, Inte:Ligand

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Silicon Genetics has released GeneSpring 7 and Signet 5. Enhancements in GeneSpring 7 include new support vector machines, project-based organization, a new Genome Wizard for genome import and management, and a Java API. Signet 5 (formerly called GeNet) now includes a SOAP API, a native Java plug-in API, project-based navigation, and modifiable workspaces.


Version 2.0 of Cytoscape is available at http://www.cytoscape.org. Cytoscape visualizes molecular interaction networks and integrates those interactions with gene expression profiles and other data. New features include the ability to load and save networks in SIF and GML formats, a new open-source graph library, and a new programmer API. Cytoscape is jointly developed by researchers at the Pasteur Institute, the University of California, San Diego, Memorial Sloan-Kettering Cancer Center, and the Institute of Systems Biology.


OpenEye Scientific Software has released Omega 1.8, a software package that generates multi-conformer structure databases for computer-aided drug design. New features include a new distance-bounds method to get better starting structures, and improved ring templates.


Inte:Ligand has launched a new virtual library generation package called ilib diverse. The software builds compounds by combining user-defined fragments. User-adjustable constraints allow a combinatorial approach that provides good structural diversity and fast, automated lead structure modification, according to the company.

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The Scan

Study Finds Costs of Genome Sequencing May Limit Utility in Routine Care

Researchers report in the European Journal of Human Genetics that genome sequencing for rare disease diagnoses currently has similar benefits as less expensive exome analysis.

Study Suggests Nursing Mother's Diet Can Impact Offspring's Gut Microbiome

A new Cell Host and Microbe paper finds that mice whose mothers were fed a low-fiber diet during nursing experience lasting microbiota dysbiosis and increased obesity.

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.

Study Offers Insights Into Role of Structural Variants in Cancer

A new study in Nature using cell lines shows that structural variants can enable oncogene activation.