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Genesis Enterprise System 2.5, TotalLab, NetAffx, OME 2.4.0, BRB-ArrayTools 3.2.3, eArray 3.0


Gene Logic has released Genesis Enterprise System 2.5. Users can import and analyze Affymetrix GeneChip data and annotate their samples using the system, and subscribers to Gene Logic’s BioExpress and ToxExpress databases can use it to analyze, manage, and store large amounts of array data and associated clinical, experimental, and genomic information.

Nonlinear Dynamics said last week that its TotalLab 1D gel image-analysis software is now compatible with the Apple Macintosh by using Virtual PC for Mac v7.0.

Affymetrix said that it will release an annotation update for its NetAffx analysis center in mid-March. The update will include new searches based on MeSH terms under “All Description” searches, and will provide access to the updated GenMAPP pathways. In addition, Entrez Gene will become the primary source of annotation data for the NetAffx Analysis Center. Mapping 10K and 100K array annotation support will be updated to NCBI Build 35 and dbSNP Build 123.

The OME (Open Microscopy Environment) project has released OME 2.4.0 at The release supports more advanced image analysis and classification and also includes a number of enhancements to improve the performance of the system.

Version 3.2.3 of BRB-ArrayTools is available from the National Cancer Institute at Improvements include a new plug-in for regression analysis of time series data and several bug fixes.

Agilent Technologies has launched eArray 3.0, a free Web portal for designing custom microarrays. The portal offers customers access to Agilent’s genomic content, annotation information, and probe sequences, and enables them to design custom microarrays using catalog probes, probes from their own sources, or a combination of both. Further information is available at

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The Scan

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Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

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Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.