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GeneExpress Reports, Topkat, GenBank Release 127.0


Gene Logic of Gaithersburg, Md., has released GeneExpress Reports, a pay-per-view approach to deriving focused data from its GeneExpress Suite of gene expression information.

The reports, which the company said can range from $25,000 to several hundred thousand dollars depending on the number of genes and tissue samples surveyed, are generated in response to specific queries keyed to individual genes of interest.

The company said that it has already signed on Vertex Pharmaceuticals, Athersys, Proteologics, Zycos, and an unnamed biopharmaceutical company as GeneExpress Reports customers.


Accelrys, the San Diego-based software subsidiary of Pharmacopeia, has released version 6.1 of Topkat, its program for the in silico estimation of toxicological properties of small molecules.

The new release includes Topkat Batch, which enables users to profile up to 1,000 compounds automatically. Topkat 6.1 also provides three new models for assessing a human therapeutic for potential toxicity: Rabbit Skin Irritancy, Rat Inhalation LC50, and Rat Maximum Tolerated Dose.


GenBank Release 127.0 is now available via FTP from the National Center for Biotechnology Information at

Release 127.0 contains 15,849,921,438 base pairs and 14,976,310 entries, up by 1.453 billion base pairs and 1,374,048 sequence records from the October 126.0 release. According to the NCBI, these single-release increases are the second largest and the very largest in the database''s history, respectively.

Uncompressed, the 127.0 flat files require around 58.12 GB for the sequence files only while the ASN.1 version requires roughly 51.75 GB.

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