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GenBank 159.0, ActivityBase XE v7.0

The National Center for Biotechnology Information has released GenBank 159.0 here. The release contains 75,742,041,056 base pairs and 71,802,595 entries. Uncompressed, the 159.0 flat files require about 275 GB for the sequence files only. The ASN.1 version requires around 232 GB. 

IDBS has launched ActivityBase XE v7.0, which includes support for complex assay types, such as multiplexing and high-content screening, the company said.
ActivityBase XE includes new multiple curve fitting functionality and visualization tools and provides a “single environment for data capture, visualization, verification, quality control, and storage,” the company said.

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The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.