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Funding Update: NSF Bioinformatics Grants Awarded Sept. 20 — Oct. 19, 2012

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An interoperable information infrastructure for biodiversity research
Start Date: Jan. 1, 2013
Expires: Dec. 31, 2015
This grant is awarded to three investigative teams:
Wuchun Feng; Virginia Polytechnic Institute and State University; $350,000
Oyekunle Olukotun; Stanford University; $350,000
Srinivas Aluru, Charles Sing, Patrick Schnable, Jaroslaw Zola; Iowa State University; $1,300,000

According to the abstract, the funds will support a project that aims to develop techniques and software libraries that enable “scalable, efficient, high performance computing solutions for high-throughput DNA sequencing.” The investigators aim to identify a set of core functionalities that occur in many types of high-throughput sequencing applications and develop efficient parallel algorithms and high performance implementations for them; pursue mapping to HPC architectures including clusters, multicores, and graphics processing units; develop software libraries that encapsulate these functionalities; and design a domain specific language that will enable bioinformatics researchers work through automatic generation of parallel codes.


Algorithms for experimental structural biology
Start Date: Sept. 1, 2012
Expires: Jan. 31, 2013
Awarded Amount to Date: $123,323
Principal Investigator: Ramgopal Mettu
Sponsor: Tulane University

The funds will support efforts to develop formulations and algorithms for use in structural biology studies


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The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.