Modeling Protein Degradation — Evaluation of Strategies and Targets
Start Date: Nov. 15, 2013
Expires: Oct. 31, 2015
Awarded Amount to Date: $300,000
Principal Investigators: Christine Vogel, Dennis Shasha
Sponsor: New York University
According to the abstract, the funds will support the use of mass spectrometry and bioinformatics to combine proteomic data such as protein ubiquitination status and degradation, with information on protein sequence and structure to discover features that impact protein stability.
Development and Application of Multi-scale Modeling for Biomolecular Association
Start Date: May 1, 2014
Expires: April 30, 2019
Awarded Amount to Date: $351,038
Principal Investigators: Chia-en Chang
Sponsor: University of California, Riverside
According to the abstract, the investigators will combine "multi-level coarse-grained and atomistic simulations to efficiently and accurately model molecular associations and kinetic enhancement of the enzymes and nanoparticle systems." The methods developed as part of this project are expected to "improve understanding of protein-ligand binding kinetics and assist the design of nanostructures, nanoparticles, and engineered enzymes."