Integrative Analysis of the Anatomic and Genetic Landscapes in the Mouse Brain
Start Date: March 1, 2012
Expires: Feb. 28, 2015
Awarded Amounts to Date: $42,014, $526,888
Principal Investigators: Patric Lundberg, Shuiwang Ji
Sponsor: Eastern Virginia Medical School, Old Dominion University Research Foundation
Supports the development of computational methods for integrative analysis of the anatomic and genetic landscapes in the mouse brain. According to the abstract, the investigators will use hierarchical models for incorporating genome-wide and brain-wide structures. Additionally, they plan to apply tensor computation techniques to enable data compression and visualization. The researchers hope to better understand the structure and development of the mammalian brain by analyzing genetic networks that can be identified through systems-level analysis of gene expression; studying relevant molecular pathways that contribute to brain function; and understanding how disruptions to genes and molecular pathways might contribute to brain diseases.
Experimental Phylogenies to Benchmark Ancestral Sequence Reconstruction
Start Date: April 1, 2012
Expires: March 31, 2015
Awarded Amount to Date: $680,000
Principal Investigator: Eric Gaucher
Sponsor: Georgia Tech Research
Supports the development of an experimental phylogenetics application to improve accuracy in inferring ancient genes. According to the investigators, the approach will let researchers connect genotype and phenotype for ancestral sequence reconstruction methods in a manner currently not possible and it will use theoretical and computational simulations to benchmark the performances of various models.