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Funding Update: NSF Bioinformatics Grants Awarded Dec. 20, 2012 — Jan. 23, 2013

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Statistical Methods and Algorithms for Genomic Data
Start Date: Aug. 31, 2012
Expires: July. 31, 2013
Awarded Amount to Date: $48,444
Principal Investigator: Shu-Chuan Chen
Sponsor: Idaho State University

According to the abstract, the funds will support three aims. The first aim will focus on extending a method for constructing hierarchical trees from sequence data using maximum likelihood and modal inference. The second project aim will “enhance the biological realism of the ancestral mixture model to include multi-state characters; advanced models of sequence evolution; and recombination.” Finally, the investigators will work on a method for reconstructing haplotype sequences from genotype data “without knowing the parental information.” In addition, the team plans to extend the method to longer sequences “by sliding a window along longer genotype sequences, then using the information from the overlapping estimates to construct longer haplotype estimates.”


US-India Catalyzing New International Collaboration with Anna University for Computational Enzyme Design Research: Sirt 1 and Sirt 3
Start Date: Aug. 1, 2012
Expires: May 31, 2013
Awarded Amount to Date: $33,828
Principal Investigator: Raj Chakrabarti
Sponsor: Carnegie-Mellon University

According to the abstract, the funds will support an international research collaboration that will study the evolutionary dynamics of sirtuin enzymes as it relates to the binding of small molecules. The project will use computer-aided sequence and binding-site analysis of enzymes; and it will experimentally verify the predicted activities of computer-generated sequences and structures.


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