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Funding Update: NSF Bioinformatics Grants Awarded April 3 — May 16, 2014


A Sequence-indexed Reverse Genetics Resource for Maize: A Set of Lines with Single Ds-GFP Insertions Spread throughout the Genome
Start Date: April 15, 2014
Expires: March 31, 2017
Awarded Amount to Date: $661,650
Principal Investigators: Hugo Dooner, Chunguang Du
Sponsor: Rutgers University

According to the abstract, these funds will be used to "complete the production of a reverse genetics resource based on the transposon Ds that will enable the community to generate and build up a single-gene knockout resource for maize."

Development of Bioinformatic Methods for Studying Gene Expression Network Inflammation and Neuronal Regeneration
Start Date: Dec. 1, 2013
Expires: July 31, 2015
Awarded Amount to Date: $283,650
Principal Investigator: Yi Ren
Sponsor: Florida State University

The abstract states that these funds will be used to develop bioinformatic and statistical methods for studying trauma to the "central nervous system including [the] spinal cord, which provokes an inflammatory response that generates substantial secondary tissue damage and inhibits neuronal regeneration."

Genetic Architecture and the Evolution of Recombination
Start Date: April 15, 2014
Expires: March 31, 2017
Awarded Amount to Date: $269,548
Principal Investigator: Ricardo Azevedo
Sponsor: University of Houston

These funds will support the development of "new empirical and modeling frameworks for studying the evolution of genetic exchange," according to the abstract. Specifically, the investigator will "extend an existing mathematical model of virus replication to capture the short-term evolutionary dynamics of experimental virus populations; determine whether gene interactions evolve in the virus model as predicted from simpler, less realistic, models; and experimentally test the predictions obtained from the mathematical model in real virus populations."

Filed under

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.