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Funding Update: NSF Bioinformatics Grants Awarded April 3 — May 16, 2014


A Sequence-indexed Reverse Genetics Resource for Maize: A Set of Lines with Single Ds-GFP Insertions Spread throughout the Genome
Start Date: April 15, 2014
Expires: March 31, 2017
Awarded Amount to Date: $661,650
Principal Investigators: Hugo Dooner, Chunguang Du
Sponsor: Rutgers University

According to the abstract, these funds will be used to "complete the production of a reverse genetics resource based on the transposon Ds that will enable the community to generate and build up a single-gene knockout resource for maize."

Development of Bioinformatic Methods for Studying Gene Expression Network Inflammation and Neuronal Regeneration
Start Date: Dec. 1, 2013
Expires: July 31, 2015
Awarded Amount to Date: $283,650
Principal Investigator: Yi Ren
Sponsor: Florida State University

The abstract states that these funds will be used to develop bioinformatic and statistical methods for studying trauma to the "central nervous system including [the] spinal cord, which provokes an inflammatory response that generates substantial secondary tissue damage and inhibits neuronal regeneration."

Genetic Architecture and the Evolution of Recombination
Start Date: April 15, 2014
Expires: March 31, 2017
Awarded Amount to Date: $269,548
Principal Investigator: Ricardo Azevedo
Sponsor: University of Houston

These funds will support the development of "new empirical and modeling frameworks for studying the evolution of genetic exchange," according to the abstract. Specifically, the investigator will "extend an existing mathematical model of virus replication to capture the short-term evolutionary dynamics of experimental virus populations; determine whether gene interactions evolve in the virus model as predicted from simpler, less realistic, models; and experimentally test the predictions obtained from the mathematical model in real virus populations."

Filed under

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.