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Funding Update: NSF Bioinformatics Awards Through Jan. 17, 2004


Gramene: A Platform for Comparative Cereal Genomics. Start date: Dec. 15, 2003. Expires: Nov. 30, 2007. Amount: $5,500,235. Principal investigator: Lincoln Stein. Sponsor: Cold Spring Harbor Laboratory.

Supports expanded operations of Gramene (, a comparative mapping database for rice and other cereals. The project uses controlled vocabularies to describe rice genes, mutants, and varieties; high-throughput analytic techniques to annotate features on the genome; and a combination of automatic and manual annotation to discover relationships between genetic and physical maps. Specific aims include mapping between the rice and maize genomes; developing an open source genome annotation pipeline; beginning a pilot project to annotate maize mutants with the Plant Ontology; and adding advanced query tool and report functionality to the Gramene web site.

Summer Research Projects in Biosystems Modeling and Analysis. Start date: Nov. 1, 2003. Expires: Oct. 31, 2006. Amount: $335,029. Principal investigator: Satish Nair. Sponsor: University of Missouri, Columbia.

Supports a three-year Research Experience for Undergraduates (REU) site at the University of Missouri Columbia for twelve students per year during ten weeks in the summer to focus on research in the area of mathematical modeling and analysis in the biosciences. Students will work with an interdisciplinary team of faculty researchers to learn how to explore biosystems using quantitative modeling and system theory analysis.

Macromolecular Structure Database (MSD). Start date: Jan. 1, 2004. Expires: Dec. 31, 2008. Amount: $28,794,057. Principal Investigator: Helen Berman. Sponsor: Rutgers University, New Brunswick.

Funds continued development of the Protein Data Bank (, including improved data processing and automated data deposition and exchange functions. Data archiving, distribution, and query capabilities will also be improved via a new system for distribution and archiving of all PDB data, enabling comprehensive structural data analyses regardless of geographic location, local hardware, or software configuration. Finally, completion and maintenance of a comprehensive physical archive is being undertaken to ensure the preservation of primary data and of all records associated with the transactions of the database including documents describing its evolution and maintenance.


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The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.