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Funding Update: NIH Bioinformatics Grants Awarded Sept. 2 — Oct. 3, 2014

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Part 1 of 2

Project Title: Methods for Accurate and Efficient Discovery of Local Pathways
Principal Investigator: Aliferis, Constantin
Organization: New York University School of Medicine
Project Start Date: Sept. 1, 2012
Project End Date: Aug. 31, 2016
Funding Institute: NLM
FY Total Cost: $277,150


Project Title: Informatics Tools for Pharmacogenomic Discovery Using Practice-based Data
Principal Investigator: Denny, Joshua Charles
Organization: Vanderbilt University
Project Start Date: Sept. 18, 2014
Project End Date: May 31, 2018
Funding Institute: NIGMS
FY Total Cost: $648,591


Project Title: Methods for High-resolution Analysis of Genetic Effects on Gene Expression
Principal Investigator: Dermitzakis, Emmanouil
Organization: Vanderbilt University
Project Start Date: Aug. 1, 2013
Project End Date: June 30, 2016
Funding Institute: NIMH
FY Total Cost: $142,018


Project Title: Methods for High-resolution Analysis of Genetic Effects on Gene Expression
Principal Investigator: Dermitzakis, Emmanouil
Organization: Vanderbilt University
Project Start Date: Aug. 1, 2013
Project End Date: June 30, 2016
Funding Institute: NIMH
FY Total Cost: $123,230


Project Title: Computational Pharmacology
Principal Investigator: Bahar, Ivet
Organization: University of Pittsburgh
Project Start Date: N/A
Project End Date: N/A
Funding Institute: NIDDK
FY Total Cost: $139,412


Project Title: UniProt: A Centralized Protein Sequence and Function Resource
Principal Investigator: Bateman, Alex
Organization: European Molecular Biology Laboratory
Project Start Date: Sept. 18, 2014
Project End Date: May 31, 2018
Funding Institute: NHGRI
FY Total Cost: $4,650,000


Project Title: Comprehensive Glycoprotemic Tool Development for Cancer Biomarkers
Principal Investigator: Becker, Christopher
Organization: Protein Metrics
Project Start Date: Sept. 22, 2014
Project End Date: Aug 31, 2016
Funding Institute: NIGMS
FY Total Cost: $342,930


Project Title: Analytic Methods for Determining Multimodal Biomarkers for Parkinson's Disease
Principal Investigator: Bowman, Dubois
Organization: Columbia University Health Sciences
Project Start Date: Jan. 1, 2014
Project End Date: Aug 31, 2016
Funding Institute: NINDS
FY Total Cost: $295,098


Project Title: Computational Design of Specific Binding Proteins Using Leave-one Out
Principal Investigator: Bystroff, Christopher
Organization: Rensselaer Polytechnic Institute
Project Start Date: Sept. 20, 2012
Project End Date: July 31, 2017
Funding Institute: NIGMS
FY Total Cost: $317,161


Project Title: The Cancer Genome Atlas Data Analysis Center
Principal Investigator: Chin, Lynda
Organization: Broad Institute
Project Start Date: Sept. 29, 2009
Project End Date: July 31, 2015
Funding Institute: NCI
FY Total Cost: $1,100,000


Project Title: Proteolysis In Silico: Statistics, Structural Chemistry, and Biology
Principal Investigator: Cieplak, Piotr
Organization: Sanford-Burnham Medical Research Institute
Project Start Date: Sept. 30, 2011
Project End Date: Aug. 31, 2015
Funding Institute: NIGMS
FY Total Cost: $370,500


Project Title: Pharmacokinetic/Pharmacodynamic Systems Modeling and Analysis
Principal Investigator: D'Argenio, David
Organization: University of Southern California
Project Start Date: N/A
Project End Date: N/A
Funding Institute: NIBIB
FY Total Cost: $217,363


Project Title: Structural Bioinformatics Software for Epitope Selection and Antibody Engineering
Principal Investigator: Darnell, Steven Joseph
Organization: DNAStar
Project Start Date: May 15, 2012
Project End Date: June 30, 2016
Funding Institute: NIGMS
FY Total Cost: $746,428


Project Title: Association Analysis Software for Mining Clinical Next-gen Sequencing Data
Principal Investigator: Durfee, Timothy
Organization: DNAStar
Project Start Date: Sept. 25, 2012
Project End Date: June 30, 2015
Funding Institute: NHGRI
FY Total Cost: $477,977


Project Title: Integrated Chemoselective and Informatic Platform for Large-scale Metabolomics
Principal Investigator: Fan, Teresa Whei-Mei
Organization: University of Kentucky
Project Start Date: April 26, 2014
Project End Date: Aug. 31, 2017
Funding Institute: NIEHS
FY Total Cost: $443,605


Project Title: An Open Resource to Advance Computer-aided Drug Design
Principal Investigator: Feher, Victoria Ann
Organization: University of California, San Diego
Project Start Date: Sept. 15, 2014
Project End Date: Aug. 31, 2019
Funding Institute: NIGMS
FY Total Cost: $728,423


Project Title: Protein Sequencing Tools for Biological Therapeutics
Principal Investigator: Fenyo, David
Organization: Protein Metrics
Project Start Date: Sept. 3, 2012
Project End Date: Aug. 31, 2015
Funding Institute: NIGMS
FY Total Cost: $108,846


Project Title: Computational Methods for Structural-Functional Studies of Protein
Principal Investigator: Grishin, Nick
Organization: UT Southwestern Medical Center
Project Start Date: July 1, 2010
Project End Date: Aug. 31, 2018
Funding Institute: NIGMS
FY Total Cost: $288,292


Project Title: Statistical ICA Methods for Analysis and Integration of Multi-Dimensional Data
Principal Investigator: Guo, Ying
Organization: Emory University
Project Start Date: Sept. 25, 2014
Project End Date: July 31, 2018
Funding Institute: NIMH
FY Total Cost: $383,210


Project Title: Genomic Resource Grant for PhenX Toolkit
Principal Investigator: Hamilton, Carol
Organization: Research Triangle Institute
Project Start Date: July 1, 2013
Project End Date: April 30, 2017
Funding Institute: NHGRI
FY Total Cost: $528,723


Project Title: An Ontology for Microbial Phenotypes
Principal Investigator: Hu, James
Organization: Texas A&M Agrilife Research
Project Start Date: April 1, 2010
Project End Date: June 30, 2017
Funding Institute: NIGMS
FY Total Cost: $297,305


Project Title: Computational and Biological Deconvolution of Epigenomic Datasets
Principal Investigator: Ince, Tan
Organization: University of Miami School of Medicine
Project Start Date: Sept. 24, 2014
Project End Date: Sept. 18, 2015
Funding Institute: NIEHS
FY Total Cost: $323,241


Project Title: Preprocessing and Analysis Tools for Contemporary Microarray Applications
Principal Investigator: Irizarry, Rafael Angel
Organization: Dana Farber Cancer Institute
Project Start Date: Sept. 24, 2007
Project End Date: Aug. 31, 2016
Funding Institute: NIGMS
FY Total Cost: $254,492


Project Title: Integrative Analyses of Reference Epigenomic Maps and Applications
Principal Investigator: Johnson, William Evan
Organization: Boston University Medical Campus
Project Start Date: Sept. 18, 2014
Project End Date: Aug. 31, 2016
Funding Institute: NIEHS
FY Total Cost: $337,445


Project Title: The UCSC Genome Browser
Principal Investigator: Kent, William James
Organization: University Of California, Santa Cruz
Project Start Date: July 12, 2001
Project End Date: June 30, 2017
Funding Institute: NHGRI
FY Total Cost: $292,515


Project Title: Integrating Epigenomic Maps to Predict Regulatory Functions of Genetic Variants
Principal Investigator: Liu, Chunyu
Organization: University Of Illinois, Chicago
Project Start Date: Sept. 10, 2014
Project End Date: Aug. 31, 2016
Funding Institute: NIEHS
FY Total Cost: $325,984


The Scan

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.

DNA Biobank Developed for French Kidney Donors, Recipients

The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France.

Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut

By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site.

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.