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Funding Update: NIH Bioinformatics Grants Awarded June 3 — July 9, 2014: Jul 11, 2014

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Part 1 of 3

Project Title: Data Fusion: A Sustainable, Scalable, Open Source Registry Advancing PVD Research
Principal Investigator: Abman, Steven
Organization: University of Colorado, Denver
Project Start Date: July 1, 2014
Project End Date: April 30, 2018
Funding Institute: NHLBI
FY Total Cost: $1,785,835


Project Title: The Protein Structure Initiative Knowledgebase
Principal Investigator: Adams, Paul
Organization: Rutgers, The State University of New Jersey
Project Start Date: Not listed
Project End Date: Not listed
Funding Institute: NIGMS
FY Total Cost: $202,906


Project Title: High Resolution Structure Modeling with Rosetta
Principal Investigator: Baker, David
Organization: University of Washington
Project Start Date: April 1, 2010
Project End Date: May 31, 2018
Funding Institute: NIGMS
FY Total Cost: $278,969


Project Title: Retention of Somatic Mutations in Cancers by Changes in PH Sensing
Principal Investigator: Barber, Diane
Organization: University of California, San Francisco
Project Start Date: July 1, 2013
Project End Date: June 30, 2015
Funding Institute: NCI
FY Total Cost: $166,671


Project Title: Implementing Appropriate Multivariate Methods for Higher Quality Results from …
Principal Investigator: Beaton, Derek
Organization: University of Texas, Dallas
Project Start Date: July 1, 2013
Project End Date: June 30, 2016
Funding Institute: NIDA
FY Total Cost: $41,795


Project Title: Constitutive and Agent-based Multiscale Models to Improve Vein Graft Survival
Principal Investigator: Berceli, Scott
Organization: University of Florida
Project Start Date: Aug.8, 2013
Project End Date: June 30, 2018
Funding Institute: NHLBI
FY Total Cost: $549,636


Project Title: Swiss Institute of Bioinformatics
Principal Investigator: Berman, Helen
Organization: Rutgers, The State University of New Jersey
Project Start Date: Not listed
Project End Date: Not listed
Funding Institute: NIGMS
FY Total Cost: $385,126


Project Title: The Protein Structure Initiative Knowledgebase
Principal Investigator: Berman, Helen
Organization: Rutgers, The State University of New Jersey
Project Start Date: July 1, 2010
Project End Date: June 30, 2015
Funding Institute: NIGMS
FY Total Cost: $2,589,526


Project Title: BigData: Low-memory Streaming Prefilters for Biological Sequencing Data
Principal Investigator: Brown, Charles Titus
Organization: Michigan State University
Project Start Date: July 19, 2013
Project End Date: May 31, 2016
Funding Institute: NHGRI
FY Total Cost: $204,209


Project Title: Robust Approaches to the Development and Evaluation of Prognostic Classifiers
Principal Investigator: Cai, Tianxi
Organization: Harvard College
Project Start Date: June 1, 2007
Project End Date: June 30, 2015
Funding Institute: NIGMS
FY Total Cost: $161,500


Project Title: Clinical Prioritization of Reported Disease Variants in Asymptomatic Individuals
Principal Investigator: Cassa, Christopher
Organization: Brigham and Womens Hospital
Project Start Date: July 1, 2013
Project End Date: June 30, 2015
Funding Institute: NHGRI
FY Total Cost: $109,080


Project Title: Molecular Dynamics Simulations of Protein Unfolding
Principal Investigator: Daggett, Valerie
Organization: University of Washington
Project Start Date: Aug. 1, 1995
Project End Date: June 30, 2015
Funding Institute: NIGMS
FY Total Cost: $288,719


Project Title: Accurate Accessible Cloud Software for Protein Folding for Molecular Biologists
Principal Investigator: Darnell, Stephen
Organization: DNAStar
Project Start Date: June 10, 2014
Project End Date: Dec. 9, 2014
Funding Institute: NIGMS
FY Total Cost: $150,000


Project Title: Visant-Predictome: A System for Integration, Mining, Visualization, and Analysis
Principal Investigator: Delisi, Charles
Organization: Boston University
Project Start Date: July 1, 2007
Project End Date: June 30, 2016
Funding Institute: NIGMS
FY Total Cost: $763,873


Project Title: Proj3: Enhancing Crystallization by Supplying Natural Binding Partners
Principal Investigator: Eisenberg, David
Organization: Los Alamos National Laboratory
Project Start Date: Not listed
Project End Date: Not listed
Funding Institute: NIGMS
FY Total Cost: $207,335


Project Title: Data-driven Approach for Identifying Subgroups Using FMRI Connectivity Maps
Principal Investigator: Gates, Kathleen
Organization: University of North Carolina, Chapel Hill
Project Start Date: July 1, 2013
Project End Date: June 30, 2015
Funding Institute: NIBIB
FY Total Cost: $216,911


Project Title: Integrated Genome Discovery at Single Base Pair Resolution
Principal Investigator: Gifford, David
Organization: Massachusetts Institute of Technology
Project Start Date: Sept. 17, 2012
Project End Date: June 30, 2015
Funding Institute: NHGRI
FY Total Cost: $648,371


Project Title: The Protein Structure Initiative Knowledgebase
Principal Investigator: Goodsell, David
Organization: Rutgers, The State University of New Jersey
Project Start Date: Not listed
Project End Date: Not listed
Funding Institute: NIGMS
FY Total Cost: $20,580


Project Title: Statistical Methods for Longitudinal Studies
Principal Investigator: Heagerty, Patrick
Organization: University of Washington
Project Start Date: Apr. 25, 2003
Project End Date: June 30, 2015
Funding Institute: NHLBI
FY Total Cost: $282,583


Project Title: Powerful Simulation Tools for the Genomics Age
Principal Investigator: Hernandez, Ryan
Organization: University of California, San Francisco
Project Start Date: June 19, 2014
Project End Date: April 30, 2019
Funding Institute: NHGRI
FY Total Cost: $390,158


Project Title: Enhancing the GMOD Suite of Genome Annotation and Visualization Tools
Principal Investigator: Holmes, Ian
Organization: University of California, Berkeley
Project Start Date: Sept. 1, 2007
Project End Date: April 30, 2017
Funding Institute: NHGRI
FY Total Cost: $399,999


Project Title: Systems Genetic and Reverse Phenotypic Analysis of Age and Retirement
Principal Investigator: Horvath, Steve
Organization: University of California, Los Angeles
Project Start Date: July 1, 2013
Project End Date: Jan. 31, 2017
Funding Institute: NIA
FY Total Cost: $315,700


Project Title: Resource for Analysis, Visualization, and Integration of Networks (RAVIN)
Principal Investigator: Ideker, Trey
Organization: University of California, San Diego
Project Start Date: Sept. 13, 2010
Project End Date: June 30, 2015
Funding Institute: NIGMS
FY Total Cost: $1,107,724


Project Title: The MetaCyc and BioCyc Pathway/Genome Databases
Principal Investigator: Karp, Peter
Organization: SRI International
Project Start Date: June 19, 2007
Project End Date: May 31, 2015
Funding Institute: NIGMS
FY Total Cost: $1,215,153


Project Title: Molecular Recognition of Proteins and Ligands Design
Principal Investigator: Jorgensen, William
Organization: Yale University
Project Start Date: July 1, 1990
Project End Date: June 30, 2015
Funding Institute: NIGMS
FY Total Cost: $369,146


Project Title: New Statistical Methods for Medical Signals and Images
Principal Investigator: Johnstone, Iain
Organization: Stanford University
Project Start Date: Sept. 10, 1996
Project End Date: June 30, 2015
Funding Institute: NIBIB
FY Total Cost: $369,239


Project Title: The X-factor of Complex Disease: From Population Genetics to GWAS of Chromosome X
Principal Investigator: Keinan, Alon
Organization: Cornell University
Project Start Date: Sept. 9, 2013
Project End Date: June 30, 2016
Funding Institute: NHGRI
FY Total Cost: $372,655


Project Title: An Integrated Computational and Functional Genomics Discovery Engine for Preclini[cal]…
Principal Investigator: Kemp, Christopher
Organization: Fred Hutchinson Cancer Research Center
Project Start Date: June 18, 2013
Project End Date: April 30, 2017
Funding Institute: NCI
FY Total Cost: $1,013,016


Project Title: Statistical Methods for Annotating Repetitive Genomic Regions Through ENCODE …
Principal Investigator: Keles, Sunduz
Organization: University of Wisconsin-Madison
Project Start Date: Sept. 17, 2012
Project End Date: June 30, 2015
Funding Institute: NHGRI
FY Total Cost: $415,499


Project Title: The UCSC Genome Browser
Principal Investigator: Kent, William
Organization: University of California, Santa Cruz
Project Start Date: July 12, 2001
Project End Date: June 30, 2017
Funding Institute: NHGRI
FY Total Cost: $3,501,582


Project Title: Identification of Protein-Metabolite Interactome
Principal Investigator: Kihara, Daisuke
Organization: Purdue University
Project Start Date: Sept. 1, 2011
Project End Date: May 31, 2015
Funding Institute: NIGMS
FY Total Cost: $278,251


Project Title: Mathematical Models for Immune Signatures from Population- and Single-Cell-base…
Principal Investigator: Klienstein, Steven
Organization: Yale University
Project Start Date: Not listed
Project End Date: Not listed
Funding Institute: NIAID
FY Total Cost: $577,028


Project Title: New Computational Methods for Analyzing the Response to Vaccination and Infection
Principal Investigator: Koller, Daphne
Organization: Stanford University
Project Start Date: Not listed
Project End Date: Not listed
Funding Institute: NIAID
FY Total Cost: $128,279

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The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.