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Funding Update: NIH Bioinformatics Grants Awarded Jan. 11 — Feb. 7, 2013

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Project Title: Computationally Optimized Anti-Staphylococcal Biotherapeutics
Principal Investigator: Bailey-Kellogg, Chris
Organization: Dartmouth College
Project Start Date: Feb. 1, 2012
Project End Date: Jan. 31, 2014
Funding Institute: NIAID
FY Total Cost: $238,613


Project Title: An Alignment Free Network Approach to Analyzing Highly Recombinant Malaria Parasite
Principal Investigator: Buckee, Caroline O'Flaherty
Organization: Harvard University, School of Public Health
Project Start Date: Feb. 1, 2013
Project End Date: Jan. 31, 2015
Funding Institute: NIGMS
FY Total Cost: $209,334


Project Title: Mapping Expression Quantitative Trait Loci with Next Generation Sequencing in SLE
Principal Investigator: Chen, Min
Organization: University of Texas, Southwest Medical Center
Project Start Date: Feb. 1, 2013
Project End Date: Jan. 31, 2017
Funding Institute: NIAMS
FY Total Cost: $120,150


Project Title: Robust and Portable Workflow-based Tools for mRNA and Genome Re-sequencing
Principal Investigator: Chen, Ting
Organization: University of Southern California
Project Start Date: Feb. 1, 2012
Project End Date: Dec. 31, 2014
Funding Institute: NHGRI
FY Total Cost: $298,728


Project Title: Statistical Tools for Whole Genome Prediction of Complex Traits and Diseases
Principal Investigator: De Los Campos, Gustavo
Organization: University of Alabama, Birmingham
Project Start Date: Mar. 1, 2012
Project End Date: Jan. 31, 2015
Funding Institute: NIGMS
FY Total Cost: $224,145


Project Title: Cancer Susceptibility Variant Discovery in High Throughput Sequencing Data
Principal Investigator: Ding, Li
Organization: Washington University
Project Start Date: Feb. 1, 2013
Project End Date: Jan. 31, 2017
Funding Institute: NCI
FY Total Cost: $202,837


Project Title: A Turnkey System for High-Throughput Variant Discovery and Interpretation
Principal Investigator: Ding, Li
Organization: Washington University
Project Start Date: Feb. 1, 2012
Project End Date: Dec. 31, 2015
Funding Institute: NHGRI
FY Total Cost: $708,567


Project Title: Statistical Methods for Ultra High-Dimensional Biomedical Data
Principal Investigator: Fan, Jianqing
Organization: Princeton University
Project Start Date: Feb. 1, 2006
Project End Date: Jan. 31, 2014
Funding Institute: NIGMS
FY Total Cost: $237,193


Project Title: Statistical Analysis Methods and Software for ChIP-Seq Data
Principal Investigator: Keles, Sunduz
Organization: University of Wisconsin, Madison
Project Start Date: July 1, 2005
Project End Date: Dec. 31, 2015
Funding Institute: NHGRI
FY Total Cost: $295,243


Project Title: Robust Software Tools for Variant Identification and Functional Assessment
Principal Investigator: Marth, Gabor
Organization: Boston College
Project Start Date: Feb. 1, 2012
Project End Date: Dec. 31, 2015
Funding Institute: NHGRI
FY Total Cost: $119,957


Project Title: Accurate Analysis of Genome Structural Variation Using Large-Scale Sequence Data
Principal Investigator: McCarroll, Steven Andrew
Organization: Harvard University Medical School
Project Start Date: Feb. 1, 2012
Project End Date: Dec. 31, 2015
Funding Institute: NHGRI
FY Total Cost: $374,808


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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.