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Funding Update: Sep 3, 2010

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NIH bioinformatics grants awarded July 27 — Aug. 25, 2010 (Part two of two. Part one is available here.)

Project Title: Statistical Methods for Next-Gen Sequencing in Disease Association Studies
Principal Investigator: Martin, Eden
Organization: University of Miami School of Medicine
Project Start Date: Sept. 30, 2009
Project End Date: July 31, 2011
RFA/PA: RFA-OD-09-004
Funding Institute: NHGRI
FY Total Cost: $500,000


Project Title: Prediction of Protein Crystallization and Diffraction Quality
Principal Investigator: Merritt, Ethan
Organization: University of Washington
Project Start Date: Aug. 1, 2009
Project End Date: July 31, 2011
RFA/PA: PAR-06-411
Funding Institute: NIGMS
FY Total Cost: $231,660


Project Title: Epigenomics Data Analysis and Coordination Center at Baylor College of Medicine
Principal Investigator: Beaudet, Arthur
Organization: Baylor College of Medicine
Project Start Date: Sept. 20, 2008
Project End Date: July 31, 2013
RFA/PA: RFA-RM-07-014
Funding Institute: OD
FY Total Cost: $1,350,927


Project Title: Bioinformatics Strategies: Biodefense Vaccine Research
Principal Investigator: Moore, Jason
Organization: Dartmouth College
Project Start Date: Aug. 1, 2004
Project End Date: July 31, 2013
RFA/PA: PAR-07-344
Funding Institute: NIAID
FY Total Cost: $481,909


Project Title: Genome-Wide Prediction and Analysis of Coding Variants
Principal Investigator: Murphy, Sean
Organization: J. Craig Venter Institute
Project Start Date: Sept. 1, 2008
Project End Date: June 30, 2012
RFA/PA: PAR-07-235
Funding Institute: NHGRI
FY Total Cost: $286,848


Project Title: A Resource for Biomedical Ontologies and Knowledge Bases
Principal Investigator: Musen, Mark
Organization: Stanford University
Project Start Date: June 1, 2003
Project End Date: Dec. 31, 2011
RFA/PA: PAR-04-142
Funding Institute: NLM
FY Total Cost: $956,625


Project Title: Evolutionary Analysis of Bacterial Genomes: High-Throughput Computational Tools
Principal Investigator: Nakhleh, Luay
Organization: Rice University
Project Start Date: Aug. 15, 2008
Project End Date: Aug. 14, 2013
RFA/PA: PA-07-070
Funding Institute: NLM
FY Total Cost: $260,529


Project Title: Cloud-Computing MapReduce to Search for Post-Translationally Modified Peptides
Principal Investigator: Nilsson, Erik
Organization: InSilicos
Project Start Date: Aug. 20, 2010
Project End Date: July 31, 2011
RFA/PA: PAR-09-220
Funding Institute: NHGRI
FY Total Cost: $179,499


Project Title: Software & Hardware Inference Engines for Automated Determination of Primary Cell
Principal Investigator: Nolan, Garry
Organization: Stanford University
Project Start Date: Sept. 26, 2008
Project End Date: July 31, 2012
RFA/PA: PAR-06-459
Funding Institute: NCI
FY Total Cost: $1,690,593


Project Title: Statistical Methods for Estimation of Copy Number from Next-Generation Sequencing
Principal Investigator: Park, Peter
Organization: Harvard University Medical School
Project Start Date: Sept. 22, 2009
Project End Date: June 30, 2011
RFA/PA: RFA-OD-09-003
Funding Institute: OD
FY Total Cost: $376,168


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Project Title: Assembly and Analysis Software for Exploring the Human Microbiome
Principal Investigator: Pop, Mihai
Organization: University of Maryland College Park Campus
Project Start Date: Sept. 24, 2008
Project End Date: July 31, 2011
RFA/PA: RFA-RM-08-008
Funding Institute: OD
FY Total Cost: $257,400


Project Title: Gene Mapping of Complex Traits Using Resequencing Data
Principal Investigator: Rocha Abecasis, Goncalo
Organization: University of Michigan at Ann Arbor
Project Start Date: Sept. 25, 2008
Project End Date: June 30, 2011
RFA/PA: RFA-MH-08-040
Funding Institute: NIMH
FY Total Cost: $371,308


Project Title: Computational Methods for Directed Functional Genomics
Principal Investigator: Roth, Frederick
Organization: Harvard University Medical School
Project Start Date: Aug. 6, 2010
Project End Date: Aug. 31, 2011
RFA/PA: PAR-03-106
Funding Institute: NHGRI
FY Total Cost: $169,176


Project Title: New Tools for Exploring the Dynamic Interactome (Renewal)
Principal Investigator: Rout, Michael
Organization: Rockefeller University
Project Start Date: Sept. 30, 2005
Project End Date: July 31, 2014
RFA/PA: RFA-RM-08-021
Funding Institute: OD
FY Total Cost: $3,304,237


Project Title: Resource for Macromolecular Modeling and Bioinformatics
Principal Investigator: Schulten, Klaus
Organization: University of Illinois Urbana-Champaign
Project Start Date: Aug. 1, 1997
Project End Date: July 31, 2012
RFA/PA: NA
Funding Institute: NCRR
FY Total Cost: $1,674,546


Project Title: Genome Analysis: Data Accuracy Haplotyping and Mapping
Principal Investigator: Stephens, Matthew
Organization: University of Chicago
Project Start Date: Sept. 20, 2002
Project End Date: July 31, 2011
RFA/PA: PA-07-070
Funding Institute: NHGRI
FY Total Cost: $396,000


Project Title: BioGPS: Extensible Web 2.0 Gene Portal for Structured and Unstructured Annotation
Principal Investigator: Su, Andrew
Organization: Novartis Institute for Functional Genomics
Project Start Date: Aug. 1, 2008
Project End Date: July 31, 2013
RFA/PA: PAR-07-344
Funding Institute: NIGMS
FY Total Cost: $314,820


Project Title: The Gene Wiki: Community Intelligence Applied to Gene Annotation
Principal Investigator: De Alfaro, Luca
Organization: Novartis Institute for Functional Genomics
Project Start Date: Aug. 1, 2010
Project End Date: May 31, 2014
RFA/PA: PAR-09-218
Funding Institute: NIGMS
FY Total Cost: $285,938


Project Title: Computational Biology, Bioinformatics, Imaging & Proteomics Research-RCMI
Principal Investigator: Taylor, Robert
Organization: Howard University
Project Start Date: Sept. 30, 1997
Project End Date: June 30, 2014
RFA/PA: NA
Funding Institute: NCRR
FY Total Cost: $2,369,604


Project Title: Training Grant in Computational Genomics
Principal Investigator: Ungar, Lyle
Organization: University of Pennsylvania
Project Start Date: July 16, 1999
Project End Date: May 31, 2014
RFA/PA: NA
Funding Institute: NHGRI
FY Total Cost: $237,471


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Project Title: Bayesian Methods for Genomics with Variable Selection
Principal Investigator: Vannucci, Marina
Organization: Rice University
Project Start Date: April 1, 2005
Project End Date: March 31, 2011
RFA/PA: NA
Funding Institute: NHGRI
FY Total Cost: $89,985


Project Title: Novel Method to Identify Competing Protein-Protein Binders
Principal Investigator: Veshtort, Mikhail
Organization: Columbia University Health Sciences
Project Start Date: Aug. 1, 2009
Project End Date: July 31, 2011
RFA/PA: PA-06-180
Funding Institute: NLM
FY Total Cost: $80,500


Project Title: A New Paradigm for Integrated Analysis of Multiscale Genomic Imaging Datasets
Principal Investigator: Wang, Yu-Ping
Organization: Tulane University of Louisiana
Project Start Date: July 1, 2009
Project End Date: June 30, 2011
RFA/PA: PA-06-181
Funding Institute: NLM
FY Total Cost: $186,306


Project Title: A Genome-Wide Mutation Resource for C. elegans
Principal Investigator: Waterston, Robert
Organization: University of Washington
Project Start Date: Aug. 20, 2010
Project End Date: Jan. 31, 2012
RFA/PA: RFA-OD-09-004
Funding Institute: NHGRI
FY Total Cost: $2,000,021


Project Title: Integrative Pipeline for Analysis & Translational Application of TCGA Data (GDAC)
Principal Investigator: Mills, Gordon
Organization: University of Texas MD Anderson Cancer Center
Project Start Date: Sept. 29, 2009
Project End Date: July 31, 2014
RFA/PA: RFA-CA-09-010
Funding Institute: NCI
FY Total Cost: $1,491,837


Project Title: Linking Text Mining and Data Mining for Biomedical Knowledge Discovery
Principal Investigator: Wu, Cathy
Organization: University of Delaware
Project Start Date: Aug. 19, 2010
Project End Date: Aug. 18, 2013
RFA/PA: RFA-LM-09-001
Funding Institute: NLM
FY Total Cost: $150,000


Project Title: Computational and Experimental Modeling of RNA Splicing
Principal Investigator: Zhang, Michael
Organization: University of Texas Dallas
Project Start Date: Aug. 13, 2007
Project End Date: July 31, 2011
RFA/PA: NA
Funding Institute: NIGMS
FY Total Cost: $358,031


Project Title: Statistical Methods for Prospective Evaluation of Biomarkers
Principal Investigator: Zheng, Yingye
Organization: Fred Hutchinson Cancer Research Center
Project Start Date: Sept. 4, 2009
Project End Date: July 31, 2013
RFA/PA: PA-07-070
Funding Institute: NIGMS
FY Total Cost: $328,824


Project Title: Quantitiative Genetic Interaction Mapping of Disease Genes in C. elegans
Principal Investigator: Zhong, Weiwei
Organization: Rice University
Project Start Date: Sept. 10, 2008
Project End Date: June 30, 2012
RFA/PA: PAR-07-344
Funding Institute: NHGRI
FY Total Cost: $249,000


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Project Title: RNA 3D Motif Search, Atlas, and Prediction from Sequence
Principal Investigator: Zirbel, Craig
Organization: Bowling Green State University
Project Start Date: Aug. 10, 2010
Project End Date: July 31, 2014
RFA/PA: PAR-07-344
Funding Institute: NIGMS
FY Total Cost: $334,523


Project Title: Development, Evaluation, and Testing of the Sesame LIMS
Principal Investigator: Zolnai, Zsolt
Organization: University of Wisconsin Madison
Project Start Date: Sept. 1, 2007
Project End Date: July 31, 2013
RFA/PA: PAR-05-057
Funding Institute: NIGMS
FY Total Cost: $272,971


The Scan

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.

DNA Biobank Developed for French Kidney Donors, Recipients

The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France.

Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut

By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site.

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.